Distinct binding kinetics of E‐, P‐ and L‐selectins to CD44

Molecular‐level selectin‐cluster of differentiation 44 (CD44) interactions are far from clear because of the complexity and diversity of CD44 glycosylation and isoforms expressed on various types of cells. By combining experimental measurements and simulation predictions, the binding kinetics of thr...

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Veröffentlicht in:	The FEBS journal 2022-05, Vol.289 (10), p.2877-2894
Hauptverfasser:	Li, Linda, Ding, Qihan, Zhou, Jin, Wu, Yi, Zhang, Mingkun, Guo, Xingming, Long, Mian, Lü, Shouqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding binding epitope binding kinetics CD44 CD44 antigen Domains Epidermal growth factor Epitopes Free energy Glycosylation Growth factors Interfaces Isoforms Kinetics Microspheres Molecular docking Molecular dynamics Nanoparticles Rupture selectin Selectins Shear flow Simulation
Online-Zugang:	Volltext
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