Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues
Purpose The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL. Methods Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m 2 ; age, 43.0 (9.4) years; 34% females] underwent a 1-...
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| Veröffentlicht in: | European journal of nutrition 2022-04, Vol.61 (3), p.1405-1416 |
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| creator | Nunes, Catarina L. Jesus, Filipe Francisco, Ruben Matias, Catarina N. Heo, Moonseong Heymsfield, Steven B. Bosy-Westphal, Anja Sardinha, Luis B. Martins, Paulo Minderico, Cláudia S. Silva, Analiza M. |
| description | Purpose
The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL.
Methods
Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m
2
; age, 43.0 (9.4) years; 34% females] underwent a 1-year lifestyle intervention (clinicaltrials.gov ID: NCT03031951) and were randomized to intervention (IG,
n
= 49) or control groups (CG,
n
= 45), and all measurements were made at baseline and after 4 months. Fat mass (FM) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and REE by indirect calorimetry. AT was assessed through 13 different approaches, varying in how REE was predicted and/or how AT was assessed.
Results
IG underwent a mean negative energy balance (EB) of 270 (289) kcal/day,
p
|
| doi_str_mv | 10.1007/s00394-021-02742-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2604455896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2638858038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8e4656d0d7401ccd3f246bb248f9936339708c4169f6016be2b1ded76ebb341b3</originalsourceid><addsrcrecordid>eNp9kE1P3DAQhq0KVD7aP9BDZYlLLynjjzgON7RqAQmpF-jVcuJJNqskXmwHxL-v6W5B4tCDZUvz-J2Zh5AvDL4zgOo8AohaFsBZPpXkhfpAjpkUqlCclQevb6iOyEmMGwDgQrGP5EhILWpR62Py-9LZbRoekaY1hsn3OGMcIrVdwkAn7zDYhPQJh36d6OhjvKCT7echLQ6pnR2dMK2986Pvh9aOdIhxwfiJHHZ2jPh5f5-S-58_7lbXxe2vq5vV5W3RiqpMhUapSuXAVRJY2zrRcamahkvd1bVQQtQV6FYyVXcKmGqQN8yhqxQ2jZCsEafk2y53G_xD7pvMNMQWx9HO6JdouAIpy1LXKqNn79CNX8Kcp8uU0LrUIHSm-I5qQ941YGe2YZhseDYMzIt1s7NusnXz17p5if66j16aCd3rl3-aMyB2QMylucfw1vs_sX8AuMCM8w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2638858038</pqid></control><display><type>article</type><title>Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nunes, Catarina L. ; Jesus, Filipe ; Francisco, Ruben ; Matias, Catarina N. ; Heo, Moonseong ; Heymsfield, Steven B. ; Bosy-Westphal, Anja ; Sardinha, Luis B. ; Martins, Paulo ; Minderico, Cláudia S. ; Silva, Analiza M.</creator><creatorcontrib>Nunes, Catarina L. ; Jesus, Filipe ; Francisco, Ruben ; Matias, Catarina N. ; Heo, Moonseong ; Heymsfield, Steven B. ; Bosy-Westphal, Anja ; Sardinha, Luis B. ; Martins, Paulo ; Minderico, Cláudia S. ; Silva, Analiza M.</creatorcontrib><description>Purpose
The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL.
Methods
Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m
2
; age, 43.0 (9.4) years; 34% females] underwent a 1-year lifestyle intervention (clinicaltrials.gov ID: NCT03031951) and were randomized to intervention (IG,
n
= 49) or control groups (CG,
n
= 45), and all measurements were made at baseline and after 4 months. Fat mass (FM) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and REE by indirect calorimetry. AT was assessed through 13 different approaches, varying in how REE was predicted and/or how AT was assessed.
Results
IG underwent a mean negative energy balance (EB) of 270 (289) kcal/day,
p
< 0.001), resulting in a WL of − 4.8 (4.9)% and an FM loss of − 11.3 (10.8)%. Regardless of approach, AT occurred in the IG, ranging from ~ − 65 to ~ − 230 kcal/day and three approaches showed significant AT in the CG.
Conclusions
Regardless of approach, AT occurred after moderate WL in the IG. AT assessment should be standardized and comparisons among studies with different methodologies to assess AT must be avoided.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-021-02742-6</identifier><identifier>PMID: 34839398</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Basal Metabolism ; Body Composition ; Body fat ; Body temperature ; Calorimetry ; Calorimetry, Indirect ; Chemistry ; Chemistry and Materials Science ; Dual energy X-ray absorptiometry ; Energy balance ; Energy Metabolism ; Fat-free body mass ; Female ; Humans ; Immunoglobulins ; Male ; Metabolism ; Nutrition ; Obesity ; Original Contribution ; Thermogenesis ; Weight control ; Weight Loss</subject><ispartof>European journal of nutrition, 2022-04, Vol.61 (3), p.1405-1416</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8e4656d0d7401ccd3f246bb248f9936339708c4169f6016be2b1ded76ebb341b3</citedby><cites>FETCH-LOGICAL-c375t-8e4656d0d7401ccd3f246bb248f9936339708c4169f6016be2b1ded76ebb341b3</cites><orcidid>0000-0002-8616-4625 ; 0000-0002-8984-8600</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-021-02742-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-021-02742-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34839398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nunes, Catarina L.</creatorcontrib><creatorcontrib>Jesus, Filipe</creatorcontrib><creatorcontrib>Francisco, Ruben</creatorcontrib><creatorcontrib>Matias, Catarina N.</creatorcontrib><creatorcontrib>Heo, Moonseong</creatorcontrib><creatorcontrib>Heymsfield, Steven B.</creatorcontrib><creatorcontrib>Bosy-Westphal, Anja</creatorcontrib><creatorcontrib>Sardinha, Luis B.</creatorcontrib><creatorcontrib>Martins, Paulo</creatorcontrib><creatorcontrib>Minderico, Cláudia S.</creatorcontrib><creatorcontrib>Silva, Analiza M.</creatorcontrib><title>Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL.
Methods
Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m
2
; age, 43.0 (9.4) years; 34% females] underwent a 1-year lifestyle intervention (clinicaltrials.gov ID: NCT03031951) and were randomized to intervention (IG,
n
= 49) or control groups (CG,
n
= 45), and all measurements were made at baseline and after 4 months. Fat mass (FM) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and REE by indirect calorimetry. AT was assessed through 13 different approaches, varying in how REE was predicted and/or how AT was assessed.
Results
IG underwent a mean negative energy balance (EB) of 270 (289) kcal/day,
p
< 0.001), resulting in a WL of − 4.8 (4.9)% and an FM loss of − 11.3 (10.8)%. Regardless of approach, AT occurred in the IG, ranging from ~ − 65 to ~ − 230 kcal/day and three approaches showed significant AT in the CG.
Conclusions
Regardless of approach, AT occurred after moderate WL in the IG. AT assessment should be standardized and comparisons among studies with different methodologies to assess AT must be avoided.</description><subject>Adult</subject><subject>Basal Metabolism</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body temperature</subject><subject>Calorimetry</subject><subject>Calorimetry, Indirect</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Energy balance</subject><subject>Energy Metabolism</subject><subject>Fat-free body mass</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Metabolism</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Original Contribution</subject><subject>Thermogenesis</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1P3DAQhq0KVD7aP9BDZYlLLynjjzgON7RqAQmpF-jVcuJJNqskXmwHxL-v6W5B4tCDZUvz-J2Zh5AvDL4zgOo8AohaFsBZPpXkhfpAjpkUqlCclQevb6iOyEmMGwDgQrGP5EhILWpR62Py-9LZbRoekaY1hsn3OGMcIrVdwkAn7zDYhPQJh36d6OhjvKCT7echLQ6pnR2dMK2986Pvh9aOdIhxwfiJHHZ2jPh5f5-S-58_7lbXxe2vq5vV5W3RiqpMhUapSuXAVRJY2zrRcamahkvd1bVQQtQV6FYyVXcKmGqQN8yhqxQ2jZCsEafk2y53G_xD7pvMNMQWx9HO6JdouAIpy1LXKqNn79CNX8Kcp8uU0LrUIHSm-I5qQ941YGe2YZhseDYMzIt1s7NusnXz17p5if66j16aCd3rl3-aMyB2QMylucfw1vs_sX8AuMCM8w</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Nunes, Catarina L.</creator><creator>Jesus, Filipe</creator><creator>Francisco, Ruben</creator><creator>Matias, Catarina N.</creator><creator>Heo, Moonseong</creator><creator>Heymsfield, Steven B.</creator><creator>Bosy-Westphal, Anja</creator><creator>Sardinha, Luis B.</creator><creator>Martins, Paulo</creator><creator>Minderico, Cláudia S.</creator><creator>Silva, Analiza M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8616-4625</orcidid><orcidid>https://orcid.org/0000-0002-8984-8600</orcidid></search><sort><creationdate>20220401</creationdate><title>Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues</title><author>Nunes, Catarina L. ; Jesus, Filipe ; Francisco, Ruben ; Matias, Catarina N. ; Heo, Moonseong ; Heymsfield, Steven B. ; Bosy-Westphal, Anja ; Sardinha, Luis B. ; Martins, Paulo ; Minderico, Cláudia S. ; Silva, Analiza M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8e4656d0d7401ccd3f246bb248f9936339708c4169f6016be2b1ded76ebb341b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Basal Metabolism</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body temperature</topic><topic>Calorimetry</topic><topic>Calorimetry, Indirect</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Energy balance</topic><topic>Energy Metabolism</topic><topic>Fat-free body mass</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Male</topic><topic>Metabolism</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Original Contribution</topic><topic>Thermogenesis</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nunes, Catarina L.</creatorcontrib><creatorcontrib>Jesus, Filipe</creatorcontrib><creatorcontrib>Francisco, Ruben</creatorcontrib><creatorcontrib>Matias, Catarina N.</creatorcontrib><creatorcontrib>Heo, Moonseong</creatorcontrib><creatorcontrib>Heymsfield, Steven B.</creatorcontrib><creatorcontrib>Bosy-Westphal, Anja</creatorcontrib><creatorcontrib>Sardinha, Luis B.</creatorcontrib><creatorcontrib>Martins, Paulo</creatorcontrib><creatorcontrib>Minderico, Cláudia S.</creatorcontrib><creatorcontrib>Silva, Analiza M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nunes, Catarina L.</au><au>Jesus, Filipe</au><au>Francisco, Ruben</au><au>Matias, Catarina N.</au><au>Heo, Moonseong</au><au>Heymsfield, Steven B.</au><au>Bosy-Westphal, Anja</au><au>Sardinha, Luis B.</au><au>Martins, Paulo</au><au>Minderico, Cláudia S.</au><au>Silva, Analiza M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>61</volume><issue>3</issue><spage>1405</spage><epage>1416</epage><pages>1405-1416</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL.
Methods
Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m
2
; age, 43.0 (9.4) years; 34% females] underwent a 1-year lifestyle intervention (clinicaltrials.gov ID: NCT03031951) and were randomized to intervention (IG,
n
= 49) or control groups (CG,
n
= 45), and all measurements were made at baseline and after 4 months. Fat mass (FM) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and REE by indirect calorimetry. AT was assessed through 13 different approaches, varying in how REE was predicted and/or how AT was assessed.
Results
IG underwent a mean negative energy balance (EB) of 270 (289) kcal/day,
p
< 0.001), resulting in a WL of − 4.8 (4.9)% and an FM loss of − 11.3 (10.8)%. Regardless of approach, AT occurred in the IG, ranging from ~ − 65 to ~ − 230 kcal/day and three approaches showed significant AT in the CG.
Conclusions
Regardless of approach, AT occurred after moderate WL in the IG. AT assessment should be standardized and comparisons among studies with different methodologies to assess AT must be avoided.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34839398</pmid><doi>10.1007/s00394-021-02742-6</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8616-4625</orcidid><orcidid>https://orcid.org/0000-0002-8984-8600</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of nutrition, 2022-04, Vol.61 (3), p.1405-1416 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Basal Metabolism Body Composition Body fat Body temperature Calorimetry Calorimetry, Indirect Chemistry Chemistry and Materials Science Dual energy X-ray absorptiometry Energy balance Energy Metabolism Fat-free body mass Female Humans Immunoglobulins Male Metabolism Nutrition Obesity Original Contribution Thermogenesis Weight control Weight Loss |
| title | Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues |
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