Mitochondria-targeted triphenylphosphonium-based compounds inhibit FcεRI-dependent degranulation of mast cells by preventing mitochondrial dysfunction through Erk1/2

FcεRI-dependent activation and degranulation of mast cells (MC) play an important role in allergic diseases. We have previously demonstrated that triphenylphosphonium (TPP)-based antioxidant SkQ1 inhibits mast cell degranulation, but the exact mechanism of this inhibition is still unknown. This stud...

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Veröffentlicht in:	Life sciences (1973) 2022-01, Vol.288, p.120174-120174, Article 120174
Hauptverfasser:	Pavlyuchenkova, Anastasia N., Zinovkin, Roman A., Makievskaya, Ciara I., Galkin, Ivan I., Chelombitko, Maria A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Allergic diseases Animals Antioxidants Cell Degranulation Degranulation Drug development Erk1/2 kinase Extracellular signal-regulated kinase FcεRI-dependent activation Fluorescence Gene Expression Regulation Immunoglobulin E Kinases Mast cell Mast cells Mast Cells - drug effects Mast Cells - immunology Mast Cells - metabolism Mast Cells - pathology Membrane potential Mitochondria Mitochondria - drug effects Mitochondria - immunology Mitochondria - metabolism Mitochondria - pathology Mitochondrial dysfunction Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation Plastoquinone - analogs & derivatives Plastoquinone - pharmacology Rats Reactive oxygen species Receptors, IgE - genetics Receptors, IgE - metabolism Signaling Syk protein Triphenylphosphonium cations
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