Single-cell landscape of peripheral immune responses to fatal SFTS

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high fatality. Poor prognosis of SFTS has been associated with dysregulated host immunity; however, the immune patterns associated with pathophysiology involving SFTS exacerbation remain unclear. Here, we show...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-11, Vol.37 (8), p.110039-110039, Article 110039
Hauptverfasser:	Li, Hao, Li, Xiaokun, Lv, Shouming, Peng, Xuefang, Cui, Ning, Yang, Tong, Yang, Zhendong, Yuan, Chun, Yuan, Yang, Yao, Jiaying, Yuan, Zan, Li, Jiachen, Ye, Xiaolei, Zhang, Xiaoai, Zhu, Shu, Peng, Ke, Liu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents China - epidemiology Cohort Studies Complement Activation - immunology emerging infectious diseases Female hemorrhagic fever Humans Immunity - immunology Immunity - physiology Interferons - genetics Leukocytes, Mononuclear - immunology Male Monocytes - immunology peripheral immune responses Plasma Cells Retrospective Studies scRNA-seq severe fever with thrombocytopenia syndrome Severe Fever with Thrombocytopenia Syndrome - epidemiology Severe Fever with Thrombocytopenia Syndrome - immunology Single-Cell Analysis - methods T-Lymphocytes - immunology tick-borne dieseases type I interferon response Viremia
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