Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis
Purpose To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis. Methods Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area...
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| Veröffentlicht in: | International ophthalmology 2022-04, Vol.42 (4), p.1339-1345 |
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| description | Purpose
To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis.
Methods
Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area, minimum cell area, average cell area and hexagonality ratio values were evaluated by non-contact specular microscopy. Parameters recorded in both groups were compared.
Results
The mean maximum cell area was 1054,44 ± 251,14 µm
2
, minimum cell area was 152.29 ± 53.65 µm
2
and average cell area was 386.91 ± 41.73 µm
2
in acute anterior uveitis group and the mean maximum cell area was 1057.65 ± 261.23 µm
2
, minimum cell area was 147.26 ± 20.45 µm
2
and average cell area was 383.53 ± 43.12 µm
2
in the control group. There were no significant differences between the two groups in terms of maximum, minimum and average cell area (respectively,
p
= 0.080,
p
= 0.72,
p
= 0.62,
p
= 0.67). The mean cell density was 2607.74 ± 277.63 cells/ µm
2
in acute anterior uveitis group and 2669.35 ± 265.22 cells/µm
2
in the control group. (
p
= 0.358). In acute anterior uveitis group the mean coefficient of variation was 31.68 ± 8.16, hexagonality ratio was 63.85 ± 11.14 and mean central corneal thickness was 571.47 ± 55.99 µm; in control group the mean coefficient of variation was 25.29 ± 3.00, mean hexagonality ratio was 72.6 ± 4.80% and mean central corneal thickness was 534.82 ± 33.84 µm. Statistically significant differences were seen between the two groups (respectively,
P
= 0,00,
P
= 0,00,
P
= 0.02).
Conclusion
The mean central corneal thickness and coefficient of variation values were found higher, and the hexagonality ratio was found lower in acute anterior uveitis group. Our findings suggest that intraocular inflammation in anterior chamber negatively affects the endothelial function in patients with acute anterior uveitis. |
| doi_str_mv | 10.1007/s10792-021-02122-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2602642743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2602642743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4164ce7b26c541cfc1eaf9499728f4b20f646be0464ab657a99b5f29b7f9584d3</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2Fr9Ay4MiRs3U_kauCybpmqTJt3omjDcQy_NDEyBqbn_voy32qYLF-Sc5Dw8cPIi9JGSU0qI-looUZp1hNH1MNbxV-iY9op3THLy-ll_hN6VcksI0UrLt-iIiw1jpGfHaL64t-Nia0gRJ49dyhHsiCFuU93BGFrvYBzxlPK8S2O62eNhj8sMbhltxlNwORWX5j0OEc_NA7EW_DvUHbZuqYBtrJBDyni5h1BDeY_eeDsW-PBYT9Cvbxc_z390V9ffL8_PrjrHVV87QaVwoAYmXS-o846C9VpordjGi4ERL4UcgAgp7CB7ZbUees_0oLzuN2LLT9CXg3fO6W6BUs0UyrqKjZCWYpgkTAqmBG_o5xfobVpybL9rlNhwprSSjWIHat24ZPBmzmGyeW8oMWse5pCHaVmYP3mYVf3pUb0ME2z_XfkbQAP4AShtFG8gP739H-0DBW-XGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2648327976</pqid></control><display><type>article</type><title>Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Sevinc, Duygu ; Celik, Tuba ; Ugurbas, Silay Canturk ; Ugurbas, Suat Hayri</creator><creatorcontrib>Sevinc, Duygu ; Celik, Tuba ; Ugurbas, Silay Canturk ; Ugurbas, Suat Hayri</creatorcontrib><description>Purpose
To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis.
Methods
Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area, minimum cell area, average cell area and hexagonality ratio values were evaluated by non-contact specular microscopy. Parameters recorded in both groups were compared.
Results
The mean maximum cell area was 1054,44 ± 251,14 µm
2
, minimum cell area was 152.29 ± 53.65 µm
2
and average cell area was 386.91 ± 41.73 µm
2
in acute anterior uveitis group and the mean maximum cell area was 1057.65 ± 261.23 µm
2
, minimum cell area was 147.26 ± 20.45 µm
2
and average cell area was 383.53 ± 43.12 µm
2
in the control group. There were no significant differences between the two groups in terms of maximum, minimum and average cell area (respectively,
p
= 0.080,
p
= 0.72,
p
= 0.62,
p
= 0.67). The mean cell density was 2607.74 ± 277.63 cells/ µm
2
in acute anterior uveitis group and 2669.35 ± 265.22 cells/µm
2
in the control group. (
p
= 0.358). In acute anterior uveitis group the mean coefficient of variation was 31.68 ± 8.16, hexagonality ratio was 63.85 ± 11.14 and mean central corneal thickness was 571.47 ± 55.99 µm; in control group the mean coefficient of variation was 25.29 ± 3.00, mean hexagonality ratio was 72.6 ± 4.80% and mean central corneal thickness was 534.82 ± 33.84 µm. Statistically significant differences were seen between the two groups (respectively,
P
= 0,00,
P
= 0,00,
P
= 0.02).
Conclusion
The mean central corneal thickness and coefficient of variation values were found higher, and the hexagonality ratio was found lower in acute anterior uveitis group. Our findings suggest that intraocular inflammation in anterior chamber negatively affects the endothelial function in patients with acute anterior uveitis.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-02122-3</identifier><identifier>PMID: 34822052</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acute Disease ; Anterior chamber ; Cell Count ; Cell density ; Cell morphology ; Coefficient of variation ; Cornea ; Cytology ; Density ; Endothelial Cells ; Endothelium, Corneal ; Humans ; Medicine ; Medicine & Public Health ; Microscopy ; Morphology ; Ophthalmology ; Original Paper ; Statistical analysis ; Thickness ; Uveitis ; Uveitis, Anterior - diagnosis ; Variation</subject><ispartof>International ophthalmology, 2022-04, Vol.42 (4), p.1339-1345</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4164ce7b26c541cfc1eaf9499728f4b20f646be0464ab657a99b5f29b7f9584d3</citedby><cites>FETCH-LOGICAL-c375t-4164ce7b26c541cfc1eaf9499728f4b20f646be0464ab657a99b5f29b7f9584d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-021-02122-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-021-02122-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34822052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sevinc, Duygu</creatorcontrib><creatorcontrib>Celik, Tuba</creatorcontrib><creatorcontrib>Ugurbas, Silay Canturk</creatorcontrib><creatorcontrib>Ugurbas, Suat Hayri</creatorcontrib><title>Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis.
Methods
Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area, minimum cell area, average cell area and hexagonality ratio values were evaluated by non-contact specular microscopy. Parameters recorded in both groups were compared.
Results
The mean maximum cell area was 1054,44 ± 251,14 µm
2
, minimum cell area was 152.29 ± 53.65 µm
2
and average cell area was 386.91 ± 41.73 µm
2
in acute anterior uveitis group and the mean maximum cell area was 1057.65 ± 261.23 µm
2
, minimum cell area was 147.26 ± 20.45 µm
2
and average cell area was 383.53 ± 43.12 µm
2
in the control group. There were no significant differences between the two groups in terms of maximum, minimum and average cell area (respectively,
p
= 0.080,
p
= 0.72,
p
= 0.62,
p
= 0.67). The mean cell density was 2607.74 ± 277.63 cells/ µm
2
in acute anterior uveitis group and 2669.35 ± 265.22 cells/µm
2
in the control group. (
p
= 0.358). In acute anterior uveitis group the mean coefficient of variation was 31.68 ± 8.16, hexagonality ratio was 63.85 ± 11.14 and mean central corneal thickness was 571.47 ± 55.99 µm; in control group the mean coefficient of variation was 25.29 ± 3.00, mean hexagonality ratio was 72.6 ± 4.80% and mean central corneal thickness was 534.82 ± 33.84 µm. Statistically significant differences were seen between the two groups (respectively,
P
= 0,00,
P
= 0,00,
P
= 0.02).
Conclusion
The mean central corneal thickness and coefficient of variation values were found higher, and the hexagonality ratio was found lower in acute anterior uveitis group. Our findings suggest that intraocular inflammation in anterior chamber negatively affects the endothelial function in patients with acute anterior uveitis.</description><subject>Acute Disease</subject><subject>Anterior chamber</subject><subject>Cell Count</subject><subject>Cell density</subject><subject>Cell morphology</subject><subject>Coefficient of variation</subject><subject>Cornea</subject><subject>Cytology</subject><subject>Density</subject><subject>Endothelial Cells</subject><subject>Endothelium, Corneal</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Statistical analysis</subject><subject>Thickness</subject><subject>Uveitis</subject><subject>Uveitis, Anterior - diagnosis</subject><subject>Variation</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1vFSEUhonR2Fr9Ay4MiRs3U_kauCybpmqTJt3omjDcQy_NDEyBqbn_voy32qYLF-Sc5Dw8cPIi9JGSU0qI-looUZp1hNH1MNbxV-iY9op3THLy-ll_hN6VcksI0UrLt-iIiw1jpGfHaL64t-Nia0gRJ49dyhHsiCFuU93BGFrvYBzxlPK8S2O62eNhj8sMbhltxlNwORWX5j0OEc_NA7EW_DvUHbZuqYBtrJBDyni5h1BDeY_eeDsW-PBYT9Cvbxc_z390V9ffL8_PrjrHVV87QaVwoAYmXS-o846C9VpordjGi4ERL4UcgAgp7CB7ZbUees_0oLzuN2LLT9CXg3fO6W6BUs0UyrqKjZCWYpgkTAqmBG_o5xfobVpybL9rlNhwprSSjWIHat24ZPBmzmGyeW8oMWse5pCHaVmYP3mYVf3pUb0ME2z_XfkbQAP4AShtFG8gP739H-0DBW-XGQ</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Sevinc, Duygu</creator><creator>Celik, Tuba</creator><creator>Ugurbas, Silay Canturk</creator><creator>Ugurbas, Suat Hayri</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220401</creationdate><title>Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis</title><author>Sevinc, Duygu ; Celik, Tuba ; Ugurbas, Silay Canturk ; Ugurbas, Suat Hayri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4164ce7b26c541cfc1eaf9499728f4b20f646be0464ab657a99b5f29b7f9584d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute Disease</topic><topic>Anterior chamber</topic><topic>Cell Count</topic><topic>Cell density</topic><topic>Cell morphology</topic><topic>Coefficient of variation</topic><topic>Cornea</topic><topic>Cytology</topic><topic>Density</topic><topic>Endothelial Cells</topic><topic>Endothelium, Corneal</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Statistical analysis</topic><topic>Thickness</topic><topic>Uveitis</topic><topic>Uveitis, Anterior - diagnosis</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sevinc, Duygu</creatorcontrib><creatorcontrib>Celik, Tuba</creatorcontrib><creatorcontrib>Ugurbas, Silay Canturk</creatorcontrib><creatorcontrib>Ugurbas, Suat Hayri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sevinc, Duygu</au><au>Celik, Tuba</au><au>Ugurbas, Silay Canturk</au><au>Ugurbas, Suat Hayri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>42</volume><issue>4</issue><spage>1339</spage><epage>1345</epage><pages>1339-1345</pages><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To determine the structure and morphology of corneal endothelial cell layer in patients with acute anterior uveitis.
Methods
Thirty-four eyes of 34 acute anterior uveitis patients and 34 eyes of 34 healthy subjects were included. Mean cell density, coefficient of variation, maximum cell area, minimum cell area, average cell area and hexagonality ratio values were evaluated by non-contact specular microscopy. Parameters recorded in both groups were compared.
Results
The mean maximum cell area was 1054,44 ± 251,14 µm
2
, minimum cell area was 152.29 ± 53.65 µm
2
and average cell area was 386.91 ± 41.73 µm
2
in acute anterior uveitis group and the mean maximum cell area was 1057.65 ± 261.23 µm
2
, minimum cell area was 147.26 ± 20.45 µm
2
and average cell area was 383.53 ± 43.12 µm
2
in the control group. There were no significant differences between the two groups in terms of maximum, minimum and average cell area (respectively,
p
= 0.080,
p
= 0.72,
p
= 0.62,
p
= 0.67). The mean cell density was 2607.74 ± 277.63 cells/ µm
2
in acute anterior uveitis group and 2669.35 ± 265.22 cells/µm
2
in the control group. (
p
= 0.358). In acute anterior uveitis group the mean coefficient of variation was 31.68 ± 8.16, hexagonality ratio was 63.85 ± 11.14 and mean central corneal thickness was 571.47 ± 55.99 µm; in control group the mean coefficient of variation was 25.29 ± 3.00, mean hexagonality ratio was 72.6 ± 4.80% and mean central corneal thickness was 534.82 ± 33.84 µm. Statistically significant differences were seen between the two groups (respectively,
P
= 0,00,
P
= 0,00,
P
= 0.02).
Conclusion
The mean central corneal thickness and coefficient of variation values were found higher, and the hexagonality ratio was found lower in acute anterior uveitis group. Our findings suggest that intraocular inflammation in anterior chamber negatively affects the endothelial function in patients with acute anterior uveitis.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34822052</pmid><doi>10.1007/s10792-021-02122-3</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Disease Anterior chamber Cell Count Cell density Cell morphology Coefficient of variation Cornea Cytology Density Endothelial Cells Endothelium, Corneal Humans Medicine Medicine & Public Health Microscopy Morphology Ophthalmology Original Paper Statistical analysis Thickness Uveitis Uveitis, Anterior - diagnosis Variation |
| title | Evaluation of corneal endothelial cell morphology by specular microscopy in patients with acute anterior uveitis |
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