Spatial molecular profiling of a central nervous system low‐grade diffusely infiltrative tumour with INI1 deficiency featuring a high‐grade atypical teratoid/rhabdoid tumour component

We performed spatial epigenetic and transcriptomic analyses of a highly unusual low‐grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT‐INI1), which harboured a high‐grade component corresponding to an atypical teratoid/rhabdoid tumour (AT/RT). Methylation profiles of both low‐grade...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2022-04, Vol.48 (3), p.e12777-n/a
Hauptverfasser:	Dottermusch, Matthias, Schumann, Yannis, Kordes, Uwe, Hasselblatt, Martin, Neumann, Julia E.
Format:	Artikel
Sprache:	eng
Schlagworte:	atypical teratoid/rhabdoid tumour Central nervous system DNA methylation Epigenetics low‐grade diffusely infiltrative tumour with INI1 deficiency Methylation NanoString GeoMx DSP spatial molecular analysis Transcriptomics Tumors
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