Spatial molecular profiling of a central nervous system low‐grade diffusely infiltrative tumour with INI1 deficiency featuring a high‐grade atypical teratoid/rhabdoid tumour component
We performed spatial epigenetic and transcriptomic analyses of a highly unusual low‐grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT‐INI1), which harboured a high‐grade component corresponding to an atypical teratoid/rhabdoid tumour (AT/RT). Methylation profiles of both low‐grade...
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| Veröffentlicht in: | Neuropathology and applied neurobiology 2022-04, Vol.48 (3), p.e12777-n/a |
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| container_title | Neuropathology and applied neurobiology |
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| creator | Dottermusch, Matthias Schumann, Yannis Kordes, Uwe Hasselblatt, Martin Neumann, Julia E. |
| description | We performed spatial epigenetic and transcriptomic analyses of a highly unusual low‐grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT‐INI1), which harboured a high‐grade component corresponding to an atypical teratoid/rhabdoid tumour (AT/RT). Methylation profiles of both low‐grade and high‐grade components yielded high similarity with AT/RTs of the MYC subgroup, whereas RNA expression analyses revealed increased translational activity and MYC pathway activation in the high‐grade component. Close follow‐up of patients harbouring CNS LGDIT‐INI1 is warranted. |
| doi_str_mv | 10.1111/nan.12777 |
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Methylation profiles of both low‐grade and high‐grade components yielded high similarity with AT/RTs of the MYC subgroup, whereas RNA expression analyses revealed increased translational activity and MYC pathway activation in the high‐grade component. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | atypical teratoid/rhabdoid tumour Central nervous system DNA methylation Epigenetics low‐grade diffusely infiltrative tumour with INI1 deficiency Methylation NanoString GeoMx DSP spatial molecular analysis Transcriptomics Tumors |
| title | Spatial molecular profiling of a central nervous system low‐grade diffusely infiltrative tumour with INI1 deficiency featuring a high‐grade atypical teratoid/rhabdoid tumour component |
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