STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

The innate immune agonist STING (STimulator of INterferon Genes) binds its natural ligand 2'3'-cGAMP (cyclic guanosine-adenosine monophosphate) and initiates type I IFN production. This promotes systemic antigen-specific CD8 T-cell priming that eventually provides potent antitumor activity...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-02, Vol.21 (2), p.282-293
Hauptverfasser:	Perera, Samanthi A, Kopinja, Johnny E, Ma, Yanhong, Muise, Eric S, Laskey, Jason, Chakravarthy, Kalyan, Chen, Yiping, Cui, Long, Presland, Jeremy, Sathe, Manjiri, Javaid, Sarah, Minnihan, Ellen C, Ferguson, Heidi M, Piesvaux, Jennifer, Pan, Bo-Sheng, Zhao, Shuxia, Sharma, Sharad K, Woo, Hyun Chong, Pucci, Vincenzo, Knemeyer, Ian, Cemerski, Saso, Cumming, Jared, Trotter, B Wesley, Tse, Archie, Khilnani, Anuradha, Ranganath, Sheila, Long, Brian J, Bennett, David Jonathan, Addona, George H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Female Humans Immunity, Innate - immunology Immunotherapy - methods Interferons - metabolism Mice Neoplasms - immunology
Online-Zugang:	Volltext
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