SP-1154, a novel synthetic TGF-β inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice

Obesity-induced inflamed visceral adipose tissue (VAT) secretes pro-inflammatory cytokines thereby promoting systemic inflammation and insulin resistance which further exacerbate obesity-associated nonalcoholic fatty liver disease (NAFLD). Transforming growth factor (TGF)-β /Smad3 signaling plays a...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2022-01, Vol.145, p.112441-112441, Article 112441
Hauptverfasser:	Pahk, Kisoo, Lee, Sang Gil, Joung, Chanmin, Kim, Eun-Ok, Kwon, Hyun Woo, Kim, Dong Hwi, Hwang, Jong-Ik, Kim, Sungeun, Kim, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat - adverse effects Glucose Tolerance Test Inflammation Inflammation - drug therapy Inflammation - pathology Insulin Resistance Intra-Abdominal Fat - drug effects Male Mice Mice, Inbred C57BL NAFLD Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology Obesity Obesity - complications Obesity - drug therapy Positron-Emission Tomography Smad3 Smad3 Protein - metabolism TGF-β Transforming Growth Factor beta - antagonists & inhibitors Visceral fat
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