β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction

We planned to appraise the effects of β‐caryophyllene on Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in rats infarcted with isoproterenol. Rats were induced myocardial infarction by using isoproterenol (100 mg/kg body weight [b.w]). Serum creatine kinas...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-12, Vol.35 (12), p.e22907-n/a
Hauptverfasser:	Yovas, Anita, Ponnian, Stanely Mainzen Prince
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Apoptosis Apoptosis - drug effects Biomarkers - blood Body weight Calcium-binding protein Caryophyllene Caspase Caspase Inhibitors - pharmacology Caspases - metabolism Clinical trials Creatine Creatine kinase Creatine Kinase, MB Form - blood Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology fas Receptor - antagonists & inhibitors fas Receptor - metabolism Heart attacks Heart rate Heart Rate - drug effects Isoproterenol Kinases Lipid peroxidation Lipids Male Myocardial infarction Myocardial Infarction - metabolism Myocardium - enzymology Myocardium - metabolism Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Organ Size - drug effects Oxidative Stress - drug effects Peroxidation Polycyclic Sesquiterpenes - administration & dosage Polycyclic Sesquiterpenes - pharmacology Polymerase chain reaction Proteins Rats Rats, Wistar Receptors Reverse transcription Signal transduction Signal Transduction - drug effects Signaling Troponin β‐caryophyllene
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Zusammenfassung:	We planned to appraise the effects of β‐caryophyllene on Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in rats infarcted with isoproterenol. Rats were induced myocardial infarction by using isoproterenol (100 mg/kg body weight [b.w]). Serum creatine kinase‐MB, serum cardiac troponin‐T, heart weight, heart rate, and heart lipid peroxidation were greatly (p
ISSN:	1095-6670 1099-0461
DOI:	10.1002/jbt.22907