IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells

Type 2 inflammation‒related cytokine IL-13 plays a protective role in experimental papilloma induction in mice. To understand the mechanisms by which IL-13 contributes to papilloma formation, we utilized Il13rα1-knockout (KO) mice in a widely used 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoyl ph...

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Veröffentlicht in:	Journal of investigative dermatology 2022-06, Vol.142 (6), p.1565-1575.e17
Hauptverfasser:	Salomaa, Tanja, Pemmari, Toini, Määttä, Juuso, Kummola, Laura, Salonen, Niklas, González-Rodríguez, Martín, Parviainen, Liisa, Hiihtola, Lotta, Vähätupa, Maria, Järvinen, Tero A.H., Junttila, Ilkka S.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Carcinogenesis - genetics Carcinogenesis - pathology Carcinogens - toxicity Interleukin-13 - genetics Interleukin-13 Receptor alpha1 Subunit Mice Mice, Knockout Papilloma - chemically induced Papilloma - genetics Skin Neoplasms - chemically induced Skin Neoplasms - genetics Skin Neoplasms - metabolism T-Lymphocytes, Regulatory - metabolism Tetradecanoylphorbol Acetate - toxicity
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