Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF)
Heart failure with reduced ejection fraction (HFrEF) is one of the most common chronic illnesses in the United States and carries significant risk of morbidity and mortality. Use of guideline-directed medical therapy (GDMT) for patients with HFrEF has been shown to dramatically improve outcomes, but...
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| Veröffentlicht in: | The American heart journal 2022-02, Vol.244, p.107-115 |
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| creator | Ghazi, Lama Desai, Nihar R. Simonov, Michael Yamamoto, Yu O'Connor, Kyle D. Riello, Ralph J. Huang, Joanna Olufade, Temitope McDermott, James Inzucchi, Silvio E. Velazquez, Eric J. Wilson, F. Perry Ahmad, Tariq |
| description | Heart failure with reduced ejection fraction (HFrEF) is one of the most common chronic illnesses in the United States and carries significant risk of morbidity and mortality. Use of guideline-directed medical therapy (GDMT) for patients with HFrEF has been shown to dramatically improve outcomes, but adoption of these treatments remains generally low. Possible explanations for poor GDMT uptake include lack of knowledge about recommended management strategies and provider reluctance due to uncertainties regarding application of said guidelines to real-world practice. One way to overcome these barriers is by harnessing the electronic health record (EHR) to create patient-centered "best practice alerts" (BPAs) that can guide clinicians to prescribe appropriate medical therapies. If found to be effective, these low-cost interventions can be rapidly applied across large integrated healthcare systems. The PRagmatic Trial Of Messaging to Providers about Treatment of Heart Failure (PROMPT-HF) trial is a pragmatic, cluster randomized controlled trial designed to test the hypothesis that tailored and timely alerting of recommended GDMT in heart failure (HF) will result in greater adherence to guidelines when compared with usual care. PROMPT-HF has completed enrollment of 1,310 ambulatory patients with HFrEF cared for by 100 providers who were randomized to receive a BPA vs usual care. The BPA alerted providers to GDMT recommended for their patients and displayed current left ventricular ejection fraction (LVEF) along with the most recent blood pressure, heart rate, serum potassium and creatinine levels, and estimated glomerular filtration rate. It also linked to an order set customized to the patient that suggests medications within each GDMT class not already prescribed. Our goal is to examine whether tailored EHR-based alerting for outpatients with HFrEF will lead to higher rates of GDMT at 30 days post randomization when compared with usual care. Additionally, we are assessing clinical outcomes such as hospital readmissions and death between the alert versus usual care group.
Trial Registration: Clinicaltrials.gov NCT04514458 |
| doi_str_mv | 10.1016/j.ahj.2021.11.010 |
| format | Article |
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Trial Registration: Clinicaltrials.gov NCT04514458</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2021.11.010</identifier><identifier>PMID: 34808104</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Best practice ; Blood pressure ; Cardiology ; Chronic illnesses ; Clinical outcomes ; Clusters ; Congestive heart failure ; Creatinine ; Drug dosages ; Ejection fraction ; Electronic health records ; Electronic medical records ; Enrollments ; Glomerular filtration rate ; Guidelines ; Health care ; Health services ; Heart failure ; Heart Failure - drug therapy ; Heart rate ; Humans ; Internal medicine ; Intervention ; Medicine ; Morbidity ; Outpatients ; Patients ; Potassium ; Randomization ; Stroke Volume ; United States ; Ventricle ; Ventricular Dysfunction, Left ; Ventricular Function, Left</subject><ispartof>The American heart journal, 2022-02, Vol.244, p.107-115</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Feb 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-6b4920eca4b73bf8ce858335e3064a735f3fcb0aa98bffc4dfb241618a15488c3</citedby><cites>FETCH-LOGICAL-c424t-6b4920eca4b73bf8ce858335e3064a735f3fcb0aa98bffc4dfb241618a15488c3</cites><orcidid>0000-0002-9930-3575 ; 0000-0002-2633-2412 ; 0000-0002-8323-8676 ; 0000-0003-2245-7477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2615482869?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34808104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazi, Lama</creatorcontrib><creatorcontrib>Desai, Nihar R.</creatorcontrib><creatorcontrib>Simonov, Michael</creatorcontrib><creatorcontrib>Yamamoto, Yu</creatorcontrib><creatorcontrib>O'Connor, Kyle D.</creatorcontrib><creatorcontrib>Riello, Ralph J.</creatorcontrib><creatorcontrib>Huang, Joanna</creatorcontrib><creatorcontrib>Olufade, Temitope</creatorcontrib><creatorcontrib>McDermott, James</creatorcontrib><creatorcontrib>Inzucchi, Silvio E.</creatorcontrib><creatorcontrib>Velazquez, Eric J.</creatorcontrib><creatorcontrib>Wilson, F. Perry</creatorcontrib><creatorcontrib>Ahmad, Tariq</creatorcontrib><title>Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF)</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Heart failure with reduced ejection fraction (HFrEF) is one of the most common chronic illnesses in the United States and carries significant risk of morbidity and mortality. Use of guideline-directed medical therapy (GDMT) for patients with HFrEF has been shown to dramatically improve outcomes, but adoption of these treatments remains generally low. Possible explanations for poor GDMT uptake include lack of knowledge about recommended management strategies and provider reluctance due to uncertainties regarding application of said guidelines to real-world practice. One way to overcome these barriers is by harnessing the electronic health record (EHR) to create patient-centered "best practice alerts" (BPAs) that can guide clinicians to prescribe appropriate medical therapies. If found to be effective, these low-cost interventions can be rapidly applied across large integrated healthcare systems. The PRagmatic Trial Of Messaging to Providers about Treatment of Heart Failure (PROMPT-HF) trial is a pragmatic, cluster randomized controlled trial designed to test the hypothesis that tailored and timely alerting of recommended GDMT in heart failure (HF) will result in greater adherence to guidelines when compared with usual care. PROMPT-HF has completed enrollment of 1,310 ambulatory patients with HFrEF cared for by 100 providers who were randomized to receive a BPA vs usual care. The BPA alerted providers to GDMT recommended for their patients and displayed current left ventricular ejection fraction (LVEF) along with the most recent blood pressure, heart rate, serum potassium and creatinine levels, and estimated glomerular filtration rate. It also linked to an order set customized to the patient that suggests medications within each GDMT class not already prescribed. Our goal is to examine whether tailored EHR-based alerting for outpatients with HFrEF will lead to higher rates of GDMT at 30 days post randomization when compared with usual care. Additionally, we are assessing clinical outcomes such as hospital readmissions and death between the alert versus usual care group.
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Perry</au><au>Ahmad, Tariq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF)</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2022-02</date><risdate>2022</risdate><volume>244</volume><spage>107</spage><epage>115</epage><pages>107-115</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>Heart failure with reduced ejection fraction (HFrEF) is one of the most common chronic illnesses in the United States and carries significant risk of morbidity and mortality. Use of guideline-directed medical therapy (GDMT) for patients with HFrEF has been shown to dramatically improve outcomes, but adoption of these treatments remains generally low. Possible explanations for poor GDMT uptake include lack of knowledge about recommended management strategies and provider reluctance due to uncertainties regarding application of said guidelines to real-world practice. One way to overcome these barriers is by harnessing the electronic health record (EHR) to create patient-centered "best practice alerts" (BPAs) that can guide clinicians to prescribe appropriate medical therapies. If found to be effective, these low-cost interventions can be rapidly applied across large integrated healthcare systems. The PRagmatic Trial Of Messaging to Providers about Treatment of Heart Failure (PROMPT-HF) trial is a pragmatic, cluster randomized controlled trial designed to test the hypothesis that tailored and timely alerting of recommended GDMT in heart failure (HF) will result in greater adherence to guidelines when compared with usual care. PROMPT-HF has completed enrollment of 1,310 ambulatory patients with HFrEF cared for by 100 providers who were randomized to receive a BPA vs usual care. The BPA alerted providers to GDMT recommended for their patients and displayed current left ventricular ejection fraction (LVEF) along with the most recent blood pressure, heart rate, serum potassium and creatinine levels, and estimated glomerular filtration rate. It also linked to an order set customized to the patient that suggests medications within each GDMT class not already prescribed. Our goal is to examine whether tailored EHR-based alerting for outpatients with HFrEF will lead to higher rates of GDMT at 30 days post randomization when compared with usual care. Additionally, we are assessing clinical outcomes such as hospital readmissions and death between the alert versus usual care group.
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| subjects | Best practice Blood pressure Cardiology Chronic illnesses Clinical outcomes Clusters Congestive heart failure Creatinine Drug dosages Ejection fraction Electronic health records Electronic medical records Enrollments Glomerular filtration rate Guidelines Health care Health services Heart failure Heart Failure - drug therapy Heart rate Humans Internal medicine Intervention Medicine Morbidity Outpatients Patients Potassium Randomization Stroke Volume United States Ventricle Ventricular Dysfunction, Left Ventricular Function, Left |
| title | Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF) |
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