Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes

Systemic application of glucocorticoids is an essential anti-inflammatory and immune-modulating therapy for severe inflammatory or autoimmunity conditions. However, its long-term effects on articular cartilage of patients' health need to be further investigated. In this study, we studied the ef...

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Veröffentlicht in:	International journal of biological sciences 2021, Vol.17 (15), p.4140-4153
Hauptverfasser:	Chen, Liang, Ni, Zhenhong, Huang, Junlan, Zhang, Ruobin, Zhang, Jinfan, Zhang, Bin, Kuang, Liang, Sun, Xianding, Zhang, Dali, Su, Nan, Qi, Huabing, Yang, Jing, Jin, Min, Luo, Fengtao, Chen, Hangang, Zhou, Siru, Du, Xiaolan, Ouyang, Junjie, Wang, Zuqiang, Xie, Yangli, Tan, Qiaoyan, Chen, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Apoptosis Apoptosis - drug effects Arthritis Autoimmunity Autophagy Biomedical materials Bone density Bone mass Calcification Calcinosis Cartilage Cartilage (articular) Cartilage diseases Chondrocytes Chondrocytes - drug effects Chondrocytes - physiology Degeneration Destabilization Dexamethasone Dexamethasone - administration & dosage Dexamethasone - adverse effects Drug Administration Schedule Extracellular matrix Extracellular Matrix - drug effects Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Homeostasis Immunomodulation Inflammation Knee Laboratory animals Long-term effects Male Meniscus Mice Mice, Inbred C57BL Osteoarthritis Osteoarthritis - etiology Osteoarthritis - pathology Patients Phagocytosis Proteoglycans Statistical analysis Subchondral bone Surgery
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