Hsa_circ_0090002 regulates miR-186-5p/HECTD1 axis to mediate brain microvascular endothelial cell dysfunction

Ischemic injury is a common nervous disease associated with the dysfunction of human brain microvascular endothelial cells (HBMECs). Circular RNAs (circRNAs) have key roles in ischemic injury. This research aims to investigate the role and mechanism of circ_0090002 in ischemic injury. HBMECs were st...

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Veröffentlicht in:	Brain research bulletin 2022-01, Vol.178, p.97-107
Hauptverfasser:	Sun, Xiaoxia, Dai, Mingying, Liu, Xin, Wang, Huimin, Wang, Chuanlei, Fan, Xinyi, Fang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - cytology Brain - metabolism Brain - physiopathology Cell Hypoxia - physiology Cells, Cultured Endothelial Cells - metabolism Glucose - metabolism HECTD1 Hsa_circ_0090002 Humans Ischemic injury MicroRNAs - metabolism Microvessels - physiopathology MiR-186-5p Oxygen-glucose deprivation RNA, Circular - metabolism Ubiquitin-Protein Ligases - metabolism
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