Etoposide-induced protein 2.4 ameliorates high glucose-induced epithelial-mesenchymal transition by activating adenosine monophosphate-activated protein kinase pathway in renal tubular cells

Epithelial-mesenchymal transition (EMT), known as the transition of tubular epithelial cells into fibroblasts, is one of the potential mechanisms of renal fibrosis, which promotes the development of diabetic kidney disease (DKD). Etoposide-induced protein 2.4 (EI24) is known as an endoplasmic reticu...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2022-01, Vol.142, p.106117, Article 106117
Hauptverfasser:	Li, Fan, Guo, Dongwei, Zhi, Shufeng, Jia, Keqi, Wang, Yuxue, Zhang, Aobo, Pei, Yuqi, Hao, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate-activated protein kinase pathway AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Cell Line Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic kidney disease Diabetic Nephropathies - drug therapy Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferase 1 - metabolism DNA Methyltransferase 3A - metabolism DNA methyltransferases Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Etoposide-induced protein 2.4 Glucose - pharmacology Humans Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Signal Transduction - drug effects
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