Assessment of skin microcirculation in primary aldosteronism: impaired microvascular responses compared to essential hypertensives and normotensives
Primary aldosteronism (PA) is associated with considerably higher cardiovascular risk and increased prevalence of organ damage compared to essential hypertension (EH). Laser speckle contrast imaging (LSCI) has emerged as a novel non-invasive tool to assess of skin microcirculation. Our aim was to ev...
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| Veröffentlicht in: | Journal of human hypertension 2022-12, Vol.36 (12), p.1066-1071 |
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| creator | Gkaliagkousi, Eugenia Lazaridis, Antonios Anyfanti, Panagiota Stavropoulos, Konstantinos Imprialos, Konstantinos Triantafyllou, Areti Mastrogiannis, Konstantinos Douma, Stella Doumas, Michalis |
| description | Primary aldosteronism (PA) is associated with considerably higher cardiovascular risk and increased prevalence of organ damage compared to essential hypertension (EH). Laser speckle contrast imaging (LSCI) has emerged as a novel non-invasive tool to assess of skin microcirculation. Our aim was to evaluate skin microvascular function (SMF) using LSCI coupled with post-occlusive reactive hyperemia (PORH) in a group of PA patients (PAs) compared to patients with EH (EHs) and normotensive controls (NTs). We enrolled PAs, age- and gender-matched with EHs and NTs. All participants underwent SMF assessment by LSCI with PORH. We enrolled 109 participants including 29 PAs, 47 EHs, and 33 NTs. SMF was significantly impaired in PAs, including peak time (
p
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| doi_str_mv | 10.1038/s41371-021-00639-9 |
| format | Article |
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p
< 0.001) and base to peak flux (
p
< 0.001) compared to NTs and EHs. Among PAs, plasma aldosterone showed a positive correlation with occlusion flux (
p
= 0.005). Our study shows for the first time that PAs present impaired SMF as assessed with LSCI coupled with PORH, not only compared to NTs but also compared to EHs with similar blood pressure profile. Further studies are needed to investigate the clinical impact of such alterations in terms of pathophysiology and cardiovascular risk prediction.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-021-00639-9</identifier><identifier>PMID: 34802038</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/75 ; 692/700/1421 ; Aldosterone ; Antihypertensives ; Blood Pressure ; Cardiovascular diseases ; Endocrine disorders ; Epidemiology ; Health Administration ; Humans ; Hyperemia ; Hypertension ; Internal medicine ; Investigations ; Laboratories ; Laser-Doppler Flowmetry ; Lasers ; Medicine ; Medicine & Public Health ; Microcirculation ; Microvasculature ; Plasma ; Potassium ; Public Health ; Regional Blood Flow ; Skin</subject><ispartof>Journal of human hypertension, 2022-12, Vol.36 (12), p.1066-1071</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-bd288db7dfe4a9d995744cd42bfafe7bff6231850b301e3b9fff6cd1982ca1ad3</citedby><cites>FETCH-LOGICAL-c375t-bd288db7dfe4a9d995744cd42bfafe7bff6231850b301e3b9fff6cd1982ca1ad3</cites><orcidid>0000-0002-7205-4644 ; 0000-0002-6324-2475 ; 0000-0002-7269-8044 ; 0000-0002-5549-7048</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41371-021-00639-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41371-021-00639-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34802038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gkaliagkousi, Eugenia</creatorcontrib><creatorcontrib>Lazaridis, Antonios</creatorcontrib><creatorcontrib>Anyfanti, Panagiota</creatorcontrib><creatorcontrib>Stavropoulos, Konstantinos</creatorcontrib><creatorcontrib>Imprialos, Konstantinos</creatorcontrib><creatorcontrib>Triantafyllou, Areti</creatorcontrib><creatorcontrib>Mastrogiannis, Konstantinos</creatorcontrib><creatorcontrib>Douma, Stella</creatorcontrib><creatorcontrib>Doumas, Michalis</creatorcontrib><title>Assessment of skin microcirculation in primary aldosteronism: impaired microvascular responses compared to essential hypertensives and normotensives</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Primary aldosteronism (PA) is associated with considerably higher cardiovascular risk and increased prevalence of organ damage compared to essential hypertension (EH). Laser speckle contrast imaging (LSCI) has emerged as a novel non-invasive tool to assess of skin microcirculation. Our aim was to evaluate skin microvascular function (SMF) using LSCI coupled with post-occlusive reactive hyperemia (PORH) in a group of PA patients (PAs) compared to patients with EH (EHs) and normotensive controls (NTs). We enrolled PAs, age- and gender-matched with EHs and NTs. All participants underwent SMF assessment by LSCI with PORH. We enrolled 109 participants including 29 PAs, 47 EHs, and 33 NTs. SMF was significantly impaired in PAs, including peak time (
p
< 0.001) and base to peak flux (
p
< 0.001) compared to NTs and EHs. Among PAs, plasma aldosterone showed a positive correlation with occlusion flux (
p
= 0.005). Our study shows for the first time that PAs present impaired SMF as assessed with LSCI coupled with PORH, not only compared to NTs but also compared to EHs with similar blood pressure profile. Further studies are needed to investigate the clinical impact of such alterations in terms of pathophysiology and cardiovascular risk prediction.</description><subject>692/699/75</subject><subject>692/700/1421</subject><subject>Aldosterone</subject><subject>Antihypertensives</subject><subject>Blood Pressure</subject><subject>Cardiovascular diseases</subject><subject>Endocrine disorders</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Humans</subject><subject>Hyperemia</subject><subject>Hypertension</subject><subject>Internal medicine</subject><subject>Investigations</subject><subject>Laboratories</subject><subject>Laser-Doppler Flowmetry</subject><subject>Lasers</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microcirculation</subject><subject>Microvasculature</subject><subject>Plasma</subject><subject>Potassium</subject><subject>Public Health</subject><subject>Regional Blood 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of skin microcirculation in primary aldosteronism: impaired microvascular responses compared to essential hypertensives and normotensives</title><author>Gkaliagkousi, Eugenia ; Lazaridis, Antonios ; Anyfanti, Panagiota ; Stavropoulos, Konstantinos ; Imprialos, Konstantinos ; Triantafyllou, Areti ; Mastrogiannis, Konstantinos ; Douma, Stella ; Doumas, Michalis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-bd288db7dfe4a9d995744cd42bfafe7bff6231850b301e3b9fff6cd1982ca1ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/699/75</topic><topic>692/700/1421</topic><topic>Aldosterone</topic><topic>Antihypertensives</topic><topic>Blood Pressure</topic><topic>Cardiovascular diseases</topic><topic>Endocrine disorders</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Humans</topic><topic>Hyperemia</topic><topic>Hypertension</topic><topic>Internal medicine</topic><topic>Investigations</topic><topic>Laboratories</topic><topic>Laser-Doppler Flowmetry</topic><topic>Lasers</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microcirculation</topic><topic>Microvasculature</topic><topic>Plasma</topic><topic>Potassium</topic><topic>Public Health</topic><topic>Regional Blood Flow</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gkaliagkousi, Eugenia</creatorcontrib><creatorcontrib>Lazaridis, Antonios</creatorcontrib><creatorcontrib>Anyfanti, Panagiota</creatorcontrib><creatorcontrib>Stavropoulos, Konstantinos</creatorcontrib><creatorcontrib>Imprialos, Konstantinos</creatorcontrib><creatorcontrib>Triantafyllou, Areti</creatorcontrib><creatorcontrib>Mastrogiannis, Konstantinos</creatorcontrib><creatorcontrib>Douma, 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Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gkaliagkousi, Eugenia</au><au>Lazaridis, Antonios</au><au>Anyfanti, Panagiota</au><au>Stavropoulos, Konstantinos</au><au>Imprialos, Konstantinos</au><au>Triantafyllou, Areti</au><au>Mastrogiannis, Konstantinos</au><au>Douma, Stella</au><au>Doumas, Michalis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of skin microcirculation in primary aldosteronism: impaired microvascular responses compared to essential hypertensives and normotensives</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>36</volume><issue>12</issue><spage>1066</spage><epage>1071</epage><pages>1066-1071</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Primary aldosteronism (PA) is associated with considerably higher cardiovascular risk and increased prevalence of organ damage compared to essential hypertension (EH). Laser speckle contrast imaging (LSCI) has emerged as a novel non-invasive tool to assess of skin microcirculation. Our aim was to evaluate skin microvascular function (SMF) using LSCI coupled with post-occlusive reactive hyperemia (PORH) in a group of PA patients (PAs) compared to patients with EH (EHs) and normotensive controls (NTs). We enrolled PAs, age- and gender-matched with EHs and NTs. All participants underwent SMF assessment by LSCI with PORH. We enrolled 109 participants including 29 PAs, 47 EHs, and 33 NTs. SMF was significantly impaired in PAs, including peak time (
p
< 0.001) and base to peak flux (
p
< 0.001) compared to NTs and EHs. Among PAs, plasma aldosterone showed a positive correlation with occlusion flux (
p
= 0.005). Our study shows for the first time that PAs present impaired SMF as assessed with LSCI coupled with PORH, not only compared to NTs but also compared to EHs with similar blood pressure profile. Further studies are needed to investigate the clinical impact of such alterations in terms of pathophysiology and cardiovascular risk prediction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34802038</pmid><doi>10.1038/s41371-021-00639-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7205-4644</orcidid><orcidid>https://orcid.org/0000-0002-6324-2475</orcidid><orcidid>https://orcid.org/0000-0002-7269-8044</orcidid><orcidid>https://orcid.org/0000-0002-5549-7048</orcidid></addata></record> |
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| ispartof | Journal of human hypertension, 2022-12, Vol.36 (12), p.1066-1071 |
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| subjects | 692/699/75 692/700/1421 Aldosterone Antihypertensives Blood Pressure Cardiovascular diseases Endocrine disorders Epidemiology Health Administration Humans Hyperemia Hypertension Internal medicine Investigations Laboratories Laser-Doppler Flowmetry Lasers Medicine Medicine & Public Health Microcirculation Microvasculature Plasma Potassium Public Health Regional Blood Flow Skin |
| title | Assessment of skin microcirculation in primary aldosteronism: impaired microvascular responses compared to essential hypertensives and normotensives |
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