Potential risk factors of persistent postural-perceptual dizziness: a pilot study
Background Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood. Objective In this single-center...
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| Veröffentlicht in: | Journal of neurology 2022-06, Vol.269 (6), p.3075-3085 |
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| creator | Li, Ling He, Songbin Liu, Haipeng Pan, Meilun Dai, Fangyu |
| description | Background
Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood.
Objective
In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD.
Methods
Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as
p
value less than 0.05.
Results
The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (
p
|
| doi_str_mv | 10.1007/s00415-021-10899-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2600287401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2666711726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-f838782a06ccb98124b8a9f4a4926deeb37781eb68ec0aa6913475a6610f49993</originalsourceid><addsrcrecordid>eNp9kEtr3TAQRkVoSW4ef6CLYOgmG6UzkqxHdyXkBYG20KyF7CsHp76Wo7EXya-vkpuk0EVXA_rOfCMOY58QThHAfCEAhTUHgRzBOsfNDluhkoKjqt0HtgKpgNeyVntsn-geAGwJdtmeVBYADazYzx9pjuPch6HKPf2uutDOKVOVumqKmXp6Tqsp0bzkMPDy1sZpXgq-7p-e-jESfa1CNfVDmqsCrR8P2ccuDBSPXucBu704_3V2xW--X16ffbvhrUI3885Ka6wIoNu2cRaFamxwnQrKCb2OsZHGWIyNtrGFELRDqUwdtEbolHNOHrCTbe-U08MSafabnto4DGGMaSEvNICwRgEW9PM_6H1a8lh-VyitDaIRulBiS7U5EeXY-Sn3m5AfPYJ_Fu63wn0R7l-Ee1OWjl-rl2YT1-8rb4YLILcAlWi8i_nv7f_U_gGXFIsA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2666711726</pqid></control><display><type>article</type><title>Potential risk factors of persistent postural-perceptual dizziness: a pilot study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Ling ; He, Songbin ; Liu, Haipeng ; Pan, Meilun ; Dai, Fangyu</creator><creatorcontrib>Li, Ling ; He, Songbin ; Liu, Haipeng ; Pan, Meilun ; Dai, Fangyu</creatorcontrib><description>Background
Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood.
Objective
In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD.
Methods
Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as
p
value less than 0.05.
Results
The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (
p
< 0.05 for all).
Conclusion
Hypertension, CAS, WMHs, and LI are associated with PPPD, which may be potential risk factors for its development.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-021-10899-7</identifier><identifier>PMID: 34800170</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Arteriosclerosis ; Carotid artery ; Cholesterol ; Chronic illnesses ; Diabetes mellitus ; Fibrinogen ; Folic acid ; High density lipoprotein ; Hypertension ; Infarction ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Posture ; Risk factors ; Substantia alba ; Vertigo ; Vitamin B12</subject><ispartof>Journal of neurology, 2022-06, Vol.269 (6), p.3075-3085</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-f838782a06ccb98124b8a9f4a4926deeb37781eb68ec0aa6913475a6610f49993</citedby><cites>FETCH-LOGICAL-c419t-f838782a06ccb98124b8a9f4a4926deeb37781eb68ec0aa6913475a6610f49993</cites><orcidid>0000-0002-8795-1057</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-021-10899-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-021-10899-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34800170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>He, Songbin</creatorcontrib><creatorcontrib>Liu, Haipeng</creatorcontrib><creatorcontrib>Pan, Meilun</creatorcontrib><creatorcontrib>Dai, Fangyu</creatorcontrib><title>Potential risk factors of persistent postural-perceptual dizziness: a pilot study</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood.
Objective
In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD.
Methods
Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as
p
value less than 0.05.
Results
The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (
p
< 0.05 for all).
Conclusion
Hypertension, CAS, WMHs, and LI are associated with PPPD, which may be potential risk factors for its development.</description><subject>Arteriosclerosis</subject><subject>Carotid artery</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Diabetes mellitus</subject><subject>Fibrinogen</subject><subject>Folic acid</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Infarction</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Posture</subject><subject>Risk factors</subject><subject>Substantia alba</subject><subject>Vertigo</subject><subject>Vitamin B12</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtr3TAQRkVoSW4ef6CLYOgmG6UzkqxHdyXkBYG20KyF7CsHp76Wo7EXya-vkpuk0EVXA_rOfCMOY58QThHAfCEAhTUHgRzBOsfNDluhkoKjqt0HtgKpgNeyVntsn-geAGwJdtmeVBYADazYzx9pjuPch6HKPf2uutDOKVOVumqKmXp6Tqsp0bzkMPDy1sZpXgq-7p-e-jESfa1CNfVDmqsCrR8P2ccuDBSPXucBu704_3V2xW--X16ffbvhrUI3885Ka6wIoNu2cRaFamxwnQrKCb2OsZHGWIyNtrGFELRDqUwdtEbolHNOHrCTbe-U08MSafabnto4DGGMaSEvNICwRgEW9PM_6H1a8lh-VyitDaIRulBiS7U5EeXY-Sn3m5AfPYJ_Fu63wn0R7l-Ee1OWjl-rl2YT1-8rb4YLILcAlWi8i_nv7f_U_gGXFIsA</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Li, Ling</creator><creator>He, Songbin</creator><creator>Liu, Haipeng</creator><creator>Pan, Meilun</creator><creator>Dai, Fangyu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8795-1057</orcidid></search><sort><creationdate>20220601</creationdate><title>Potential risk factors of persistent postural-perceptual dizziness: a pilot study</title><author>Li, Ling ; He, Songbin ; Liu, Haipeng ; Pan, Meilun ; Dai, Fangyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-f838782a06ccb98124b8a9f4a4926deeb37781eb68ec0aa6913475a6610f49993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteriosclerosis</topic><topic>Carotid artery</topic><topic>Cholesterol</topic><topic>Chronic illnesses</topic><topic>Diabetes mellitus</topic><topic>Fibrinogen</topic><topic>Folic acid</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Infarction</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Posture</topic><topic>Risk factors</topic><topic>Substantia alba</topic><topic>Vertigo</topic><topic>Vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>He, Songbin</creatorcontrib><creatorcontrib>Liu, Haipeng</creatorcontrib><creatorcontrib>Pan, Meilun</creatorcontrib><creatorcontrib>Dai, Fangyu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ling</au><au>He, Songbin</au><au>Liu, Haipeng</au><au>Pan, Meilun</au><au>Dai, Fangyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential risk factors of persistent postural-perceptual dizziness: a pilot study</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>269</volume><issue>6</issue><spage>3075</spage><epage>3085</epage><pages>3075-3085</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background
Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood.
Objective
In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD.
Methods
Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as
p
value less than 0.05.
Results
The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (
p
< 0.05 for all).
Conclusion
Hypertension, CAS, WMHs, and LI are associated with PPPD, which may be potential risk factors for its development.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34800170</pmid><doi>10.1007/s00415-021-10899-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8795-1057</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Arteriosclerosis Carotid artery Cholesterol Chronic illnesses Diabetes mellitus Fibrinogen Folic acid High density lipoprotein Hypertension Infarction Magnetic resonance imaging Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Original Communication Posture Risk factors Substantia alba Vertigo Vitamin B12 |
| title | Potential risk factors of persistent postural-perceptual dizziness: a pilot study |
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