Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)
Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperid...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-12, Vol.40 (12), p.5812-5822 |
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| creator | Pla-Pagà, Laura Valls, Rosa M. Pedret, Anna Calderón-Pérez, Lorena Llauradó, Elisabet Companys, Judit Domenech-Coca, Cristina Canela, Nuria del Bas, Josep M. Caimari, Antoni Puiggròs, Francesc MI, Covas Arola, Lluís Solà, Rosa |
| description | Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperidin consumption in subjects with elevated blood pressure or with stage 1 hypertension, by determining their transcriptomic profile after a single dose or a 12-week treatment.
For transcriptomic analysis, peripheral blood mononuclear cells were obtained from 37 subjects with elevated blood pressure and stage 1 hypertension from CITRUS study who were randomized to receive for 12 weeks: control drink (CD; n = 11), OJ (containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of hesperidin; n = 11). Before starting the 12-weeks treatment, a single dose study with a 6 h of follow-up in each group was performed. After the single dose consumption, EOJ versus OJ, downregulated DHRS9 gene which is related with insulin resistance. Compared to CD, 12-week treatment of EOJ downregulated 6 proinflammatory genes while after OJ consumption only 1 proinflammatory gene was downregulated. Moreover, 12-week treatment of EOJ versus OJ, downregulated acute coronary syndrome gene related (SELENBP1).
A single dose consumption of EOJ could protect from insulin resistance. Moreover, EOJ decrease the expression of proinflammatory genes after 12-week treatment providing a possible mechanism of action on inflammation pathway. |
| doi_str_mv | 10.1016/j.clnu.2021.10.009 |
| format | Article |
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For transcriptomic analysis, peripheral blood mononuclear cells were obtained from 37 subjects with elevated blood pressure and stage 1 hypertension from CITRUS study who were randomized to receive for 12 weeks: control drink (CD; n = 11), OJ (containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of hesperidin; n = 11). Before starting the 12-weeks treatment, a single dose study with a 6 h of follow-up in each group was performed. After the single dose consumption, EOJ versus OJ, downregulated DHRS9 gene which is related with insulin resistance. Compared to CD, 12-week treatment of EOJ downregulated 6 proinflammatory genes while after OJ consumption only 1 proinflammatory gene was downregulated. Moreover, 12-week treatment of EOJ versus OJ, downregulated acute coronary syndrome gene related (SELENBP1).
A single dose consumption of EOJ could protect from insulin resistance. Moreover, EOJ decrease the expression of proinflammatory genes after 12-week treatment providing a possible mechanism of action on inflammation pathway.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2021.10.009</identifier><identifier>PMID: 34800819</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>3-Hydroxysteroid Dehydrogenases - metabolism ; Adult ; Blood Pressure - genetics ; Citrus sinensis ; Double-Blind Method ; Down-Regulation ; Female ; Fruit and Vegetable Juices ; Gene Expression - drug effects ; Hesperidin ; Hesperidin - administration & dosage ; Hesperidin - pharmacology ; Humans ; Hypertension - genetics ; Hypertensive subjects ; Leukocytes, Mononuclear - metabolism ; Male ; Middle Aged ; Orange juice ; PBMCs ; Plasma ; Selenium-Binding Proteins - metabolism ; Transcriptome - drug effects ; Transcriptomic analysis</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2021-12, Vol.40 (12), p.5812-5822</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-fc3c7bc5d4b7a32a71ed210b54d67c5c1e29854ffd27f425a86ff3c3232981903</citedby><cites>FETCH-LOGICAL-c356t-fc3c7bc5d4b7a32a71ed210b54d67c5c1e29854ffd27f425a86ff3c3232981903</cites><orcidid>0000-0001-6144-0294 ; 0000-0003-1589-4556 ; 0000-0003-1485-0818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2021.10.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34800819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pla-Pagà, Laura</creatorcontrib><creatorcontrib>Valls, Rosa M.</creatorcontrib><creatorcontrib>Pedret, Anna</creatorcontrib><creatorcontrib>Calderón-Pérez, Lorena</creatorcontrib><creatorcontrib>Llauradó, Elisabet</creatorcontrib><creatorcontrib>Companys, Judit</creatorcontrib><creatorcontrib>Domenech-Coca, Cristina</creatorcontrib><creatorcontrib>Canela, Nuria</creatorcontrib><creatorcontrib>del Bas, Josep M.</creatorcontrib><creatorcontrib>Caimari, Antoni</creatorcontrib><creatorcontrib>Puiggròs, Francesc</creatorcontrib><creatorcontrib>MI, Covas</creatorcontrib><creatorcontrib>Arola, Lluís</creatorcontrib><creatorcontrib>Solà, Rosa</creatorcontrib><title>Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperidin consumption in subjects with elevated blood pressure or with stage 1 hypertension, by determining their transcriptomic profile after a single dose or a 12-week treatment.
For transcriptomic analysis, peripheral blood mononuclear cells were obtained from 37 subjects with elevated blood pressure and stage 1 hypertension from CITRUS study who were randomized to receive for 12 weeks: control drink (CD; n = 11), OJ (containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of hesperidin; n = 11). Before starting the 12-weeks treatment, a single dose study with a 6 h of follow-up in each group was performed. After the single dose consumption, EOJ versus OJ, downregulated DHRS9 gene which is related with insulin resistance. Compared to CD, 12-week treatment of EOJ downregulated 6 proinflammatory genes while after OJ consumption only 1 proinflammatory gene was downregulated. Moreover, 12-week treatment of EOJ versus OJ, downregulated acute coronary syndrome gene related (SELENBP1).
A single dose consumption of EOJ could protect from insulin resistance. 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Valls, Rosa M. ; Pedret, Anna ; Calderón-Pérez, Lorena ; Llauradó, Elisabet ; Companys, Judit ; Domenech-Coca, Cristina ; Canela, Nuria ; del Bas, Josep M. ; Caimari, Antoni ; Puiggròs, Francesc ; MI, Covas ; Arola, Lluís ; Solà, Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-fc3c7bc5d4b7a32a71ed210b54d67c5c1e29854ffd27f425a86ff3c3232981903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3-Hydroxysteroid Dehydrogenases - metabolism</topic><topic>Adult</topic><topic>Blood Pressure - genetics</topic><topic>Citrus sinensis</topic><topic>Double-Blind Method</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Fruit and Vegetable Juices</topic><topic>Gene Expression - drug effects</topic><topic>Hesperidin</topic><topic>Hesperidin - administration & dosage</topic><topic>Hesperidin - pharmacology</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertensive subjects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orange juice</topic><topic>PBMCs</topic><topic>Plasma</topic><topic>Selenium-Binding Proteins - metabolism</topic><topic>Transcriptome - drug effects</topic><topic>Transcriptomic analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pla-Pagà, Laura</creatorcontrib><creatorcontrib>Valls, Rosa M.</creatorcontrib><creatorcontrib>Pedret, Anna</creatorcontrib><creatorcontrib>Calderón-Pérez, Lorena</creatorcontrib><creatorcontrib>Llauradó, Elisabet</creatorcontrib><creatorcontrib>Companys, Judit</creatorcontrib><creatorcontrib>Domenech-Coca, Cristina</creatorcontrib><creatorcontrib>Canela, Nuria</creatorcontrib><creatorcontrib>del Bas, Josep M.</creatorcontrib><creatorcontrib>Caimari, Antoni</creatorcontrib><creatorcontrib>Puiggròs, Francesc</creatorcontrib><creatorcontrib>MI, Covas</creatorcontrib><creatorcontrib>Arola, Lluís</creatorcontrib><creatorcontrib>Solà, Rosa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pla-Pagà, Laura</au><au>Valls, Rosa M.</au><au>Pedret, Anna</au><au>Calderón-Pérez, Lorena</au><au>Llauradó, Elisabet</au><au>Companys, Judit</au><au>Domenech-Coca, Cristina</au><au>Canela, Nuria</au><au>del Bas, Josep M.</au><au>Caimari, Antoni</au><au>Puiggròs, Francesc</au><au>MI, Covas</au><au>Arola, Lluís</au><au>Solà, Rosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study)</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2021-12</date><risdate>2021</risdate><volume>40</volume><issue>12</issue><spage>5812</spage><epage>5822</epage><pages>5812-5822</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of action remain undefined. In a previous study we demonstrated that a single dose and a 12-week treatment of hesperidin decreased systolic blood pressure. The aim of this study was to ascertain the action mechanisms of hesperidin consumption in subjects with elevated blood pressure or with stage 1 hypertension, by determining their transcriptomic profile after a single dose or a 12-week treatment.
For transcriptomic analysis, peripheral blood mononuclear cells were obtained from 37 subjects with elevated blood pressure and stage 1 hypertension from CITRUS study who were randomized to receive for 12 weeks: control drink (CD; n = 11), OJ (containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of hesperidin; n = 11). Before starting the 12-weeks treatment, a single dose study with a 6 h of follow-up in each group was performed. After the single dose consumption, EOJ versus OJ, downregulated DHRS9 gene which is related with insulin resistance. Compared to CD, 12-week treatment of EOJ downregulated 6 proinflammatory genes while after OJ consumption only 1 proinflammatory gene was downregulated. Moreover, 12-week treatment of EOJ versus OJ, downregulated acute coronary syndrome gene related (SELENBP1).
A single dose consumption of EOJ could protect from insulin resistance. Moreover, EOJ decrease the expression of proinflammatory genes after 12-week treatment providing a possible mechanism of action on inflammation pathway.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34800819</pmid><doi>10.1016/j.clnu.2021.10.009</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6144-0294</orcidid><orcidid>https://orcid.org/0000-0003-1589-4556</orcidid><orcidid>https://orcid.org/0000-0003-1485-0818</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2021-12, Vol.40 (12), p.5812-5822 |
| issn | 0261-5614 1532-1983 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3-Hydroxysteroid Dehydrogenases - metabolism Adult Blood Pressure - genetics Citrus sinensis Double-Blind Method Down-Regulation Female Fruit and Vegetable Juices Gene Expression - drug effects Hesperidin Hesperidin - administration & dosage Hesperidin - pharmacology Humans Hypertension - genetics Hypertensive subjects Leukocytes, Mononuclear - metabolism Male Middle Aged Orange juice PBMCs Plasma Selenium-Binding Proteins - metabolism Transcriptome - drug effects Transcriptomic analysis |
| title | Effect of the consumption of hesperidin in orange juice on the transcriptomic profile of subjects with elevated blood pressure and stage 1 hypertension: A randomized controlled trial (CITRUS study) |
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