Zinc ions coordinated carboxymethyl chitosan-hyaluronic acid microgel for pulmonary drug delivery

Microgel affords a porous and swollen microstructure for the establishment of pulmonary delivery system with sustained released properties. Here, we report a microgel (with the diameter around 4 μm) prepared with a precipitation method, synthesized by coordinating Zn2+ to the Schiff base cross-linke...

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Veröffentlicht in:	International journal of biological macromolecules 2021-12, Vol.193 (Pt B), p.1043-1049
Hauptverfasser:	Yan, Yishu, Wu, Qingqing, Ren, Panpan, Liu, Qiuyi, Zhang, Na, Ji, Yang, Liu, Jingxian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxymethyl chitosan Chitosan - analogs & derivatives Chitosan - chemistry Chitosan - pharmacokinetics Chitosan - pharmacology Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Hyaluronate Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacokinetics Hyaluronic Acid - pharmacology Lung - metabolism Mice Mice, Inbred ICR Microgel Microgels - chemistry NIH 3T3 Cells RAW 264.7 Cells Zinc - chemistry Zinc - pharmacokinetics Zinc - pharmacology
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