Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma

Purpose Cholangiocarcinoma (CCA) is a highly invasive malignant tumor originating from the bile duct epithelium. Tweety homolog 3 (TTYH3) is a member of the family of calcium-activated chloride channels, which have several biological functions. Here, we aimed to investigate the expression and biolog...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2021-12, Vol.44 (6), p.1351-1361
Hauptverfasser:	Xue, Weijie, Dong, Bingzi, Zhao, Yanjie, Wang, Yixiu, Yang, Chenyu, Xie, Yuwei, Niu, Zhaojian, Zhu, Chengzhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics beta Catenin - metabolism Bile Duct Neoplasms - metabolism Bile ducts Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology Biomedical and Life Sciences Biomedicine Calcium channels Calcium chloride Cancer Research Cell culture Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Chloride channels (calcium-gated) Chloride Channels - genetics Cholangiocarcinoma Cholangiocarcinoma - metabolism CpG islands Deoxyribonucleic acid DNA DNA methylation E-cadherin Epithelial-Mesenchymal Transition - genetics Epithelium Gene expression Gene Expression Regulation, Neoplastic Humans Mesenchyme Metastases mRNA N-Cadherin Oncology Original Article Pathology Signal transduction Tumors Up-Regulation - genetics Vimentin Wnt protein Wnt Signaling Pathway Xenografts β-Catenin
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