Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair

Functional recovery following peripheral nerve injury is limited by progressive atrophy of denervated muscle and Schwann cells (SCs) that occurs during the long regenerative period prior to end-organ reinnervation. Insulin-like growth factor 1 (IGF-1) is a potent mitogen with well-described trophic...

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Veröffentlicht in:Biomaterials 2022-01, Vol.280, p.121244-121244, Article 121244
Hauptverfasser: Hanwright, Philip J., Qiu, Chenhu, Rath, Jennifer, Zhou, Yang, von Guionneau, Nicholas, Sarhane, Karim A., Harris, Thomas G.W., Howard, Gregory P., Malapati, Harsha, Lan, Michael J., Reddy, Sashank, Hoke, Ahmet, Mao, Hai-Quan, Tuffaha, Sami H.
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Sprache:eng
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