ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression

Purpose Autophagy-dependent tumorigenic growth is one of the most commonly reported molecular mechanisms in glioblastoma (GBM) progression. However, the mechanistic correlation between autophagy and GBM is still largely unexplored, especially the roles of autophagy-related genes involved in GBM onco...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuro-oncology 2022, Vol.156 (1), p.123-137
Hauptverfasser:	Yang, Kang, Luan, Lan, Li, Xinyu, Sun, Xu, Yin, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Apoptosis Autophagy Autophagy - drug effects Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Carcinogenesis - drug effects Cell death Cell survival Extracellular signal-regulated kinase Genomes Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - pathology Humans Image processing Kinases Laboratory Investigation MAP kinase MAP Kinase Signaling System - genetics Medicine Medicine & Public Health Molecular modelling Neurology Oncology Phagocytosis Protein Kinase Inhibitors - pharmacology Rapamycin Signal transduction TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transcription Transmission electron microscopy Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!