Contribution of branched chain amino acids to energy production and mevalonate synthesis in cancer cells

Leucine, isoleucine and valine, known as branched chain amino acids (BCAAs), have been reported to be degraded by different cancer cells, and their biodegradation pathways have been suggested as anticancer targets. However, the mechanisms by which the degradation of BCAAs could support the growth of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-12, Vol.585, p.61-67
Hauptverfasser:	Mikalayeva, Valeryia, Pankevičiūtė, Monika, Žvikas, Vaidotas, Skeberdis, V. Arvydas, Bordel, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetoacetates - metabolism Algorithms Amino Acids, Branched-Chain - metabolism Branched chain amino-acids Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer metabolism Carbon - metabolism Cell Line Cell Line, Tumor Citric Acid Cycle Energy Metabolism Female Humans Leucine - metabolism MCF-7 Cells Metabolic flux analysis Metabolic Flux Analysis - methods Metabolic Networks and Pathways Mevalonic Acid - metabolism Mitochondria - metabolism Models, Biological
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