Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation

— Intestinal inflammation is a common disease which can further lead to inflammatory bowel disease and even intestinal cancer. The increasing focus has come to the role of short-chain fatty acid (SCFA) in various bowel diseases. Hence, this study was designed to explore the specific role of SCFA in...

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Veröffentlicht in:	Inflammation 2022-02, Vol.45 (1), p.372-386
Hauptverfasser:	Liu, Qian, Peng, Zemin, Zhou, Lin, Peng, Renqun, Li, Xinghui, Zuo, Wei, Gou, Juhua, Zhou, Feixue, Yu, Shuangjiang, Huang, Min, Liu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine CCAAT-Enhancer-Binding Protein-beta - immunology CCAAT-Enhancer-Binding Protein-beta - metabolism CCAAT/enhancer-binding protein Colitis - immunology Colitis - metabolism Colitis - pathology Colon - immunology Colon - metabolism Colon - pathology Disease Dual Specificity Phosphatase 6 - immunology Dual Specificity Phosphatase 6 - metabolism Epithelial cells Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Fatty acids Fatty Acids, Volatile - immunology Fatty Acids, Volatile - metabolism Histology IL-1β Immunology Inflammation Inflammatory bowel diseases Interleukin 6 Internal Medicine Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lipopolysaccharides Lipopolysaccharides - immunology Male Mice Mice, Inbred C57BL MicroRNAs - immunology MicroRNAs - metabolism miRNA Original Article Pathology Pharmacology/Toxicology Reporter gene Rheumatology Small intestine Tumor necrosis factor-α
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