Whole‐brain morphometry in Canadian soldiers with posttraumatic stress disorder
Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces w...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2022-03, Vol.1509 (1), p.37-49 |
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| creator | Roy, Olivier Levasseur‐Moreau, Jean Renauld, Emmanuelle Hébert, Luc J. Leblond, Jean Bilodeau, Mathieu Fecteau, Shirley |
| description | Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces with adulthood war‐related PTSD using structural magnetic resonance imaging. We assessed time since trauma, as well as PTSD, depressive, and anxiety symptoms with the Modified PTSD Symptoms Scale, Beck Depression Inventory, and Beck Anxiety Inventory, respectively. Whole‐brain morphometry was extracted with FreeSurfer and compared with a validated normative database of more than 2700 healthy individuals. Volume and thickness from several regions differed from the norms. Frontal regions were smaller and thinner, particularly the superior and rostral middle frontal gyri. Furthermore, smaller left rostral middle frontal gyrus, left pericalcarine cortex, and right fusiform gyrus were associated with more recent trauma. All subcortical structures were bigger, except the hippocampus. These findings suggest a particular brain morphometric signature of PTSD in soldiers. Smaller and thinner frontal and larger subcortical regions support impaired top‐down and/or downregulation of emotional response in PTSD. Finally, the correlation of smaller frontal, temporal, and occipital regions with more recent trauma might inform future therapeutic approaches.
Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers with adulthood war‐related PTSD using structural magnetic resonance imaging and compared them with a validated normative database of more than 2700 healthy individuals. |
| doi_str_mv | 10.1111/nyas.14707 |
| format | Article |
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Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers with adulthood war‐related PTSD using structural magnetic resonance imaging and compared them with a validated normative database of more than 2700 healthy individuals.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/nyas.14707</identifier><identifier>PMID: 34791677</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Anxiety ; Armed forces ; Brain ; Brain - diagnostic imaging ; Brain - pathology ; brain morphometry ; Canada ; Cortex (frontal) ; disorder duration ; Frontal gyrus ; Humans ; Magnetic Resonance Imaging ; Mental disorders ; Military ; Military Personnel - psychology ; Military psychology ; Morphometry ; Neuroimaging ; Norms ; Post traumatic stress disorder ; Psychological stress ; PTSD ; soldiers ; Stress Disorders, Post-Traumatic - diagnostic imaging ; structural MRI ; Temporal lobe ; Trauma</subject><ispartof>Annals of the New York Academy of Sciences, 2022-03, Vol.1509 (1), p.37-49</ispartof><rights>2021 New York Academy of Sciences.</rights><rights>2022 The New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3577-64e3144e2b20e444afb87beacf2847242d0d2819973b306b409a4391e622a4b93</citedby><cites>FETCH-LOGICAL-c3577-64e3144e2b20e444afb87beacf2847242d0d2819973b306b409a4391e622a4b93</cites><orcidid>0000-0002-4850-0560 ; 0000-0002-9781-4451 ; 0000-0002-4328-7828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnyas.14707$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnyas.14707$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34791677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roy, Olivier</creatorcontrib><creatorcontrib>Levasseur‐Moreau, Jean</creatorcontrib><creatorcontrib>Renauld, Emmanuelle</creatorcontrib><creatorcontrib>Hébert, Luc J.</creatorcontrib><creatorcontrib>Leblond, Jean</creatorcontrib><creatorcontrib>Bilodeau, Mathieu</creatorcontrib><creatorcontrib>Fecteau, Shirley</creatorcontrib><title>Whole‐brain morphometry in Canadian soldiers with posttraumatic stress disorder</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces with adulthood war‐related PTSD using structural magnetic resonance imaging. We assessed time since trauma, as well as PTSD, depressive, and anxiety symptoms with the Modified PTSD Symptoms Scale, Beck Depression Inventory, and Beck Anxiety Inventory, respectively. Whole‐brain morphometry was extracted with FreeSurfer and compared with a validated normative database of more than 2700 healthy individuals. Volume and thickness from several regions differed from the norms. Frontal regions were smaller and thinner, particularly the superior and rostral middle frontal gyri. Furthermore, smaller left rostral middle frontal gyrus, left pericalcarine cortex, and right fusiform gyrus were associated with more recent trauma. All subcortical structures were bigger, except the hippocampus. These findings suggest a particular brain morphometric signature of PTSD in soldiers. Smaller and thinner frontal and larger subcortical regions support impaired top‐down and/or downregulation of emotional response in PTSD. Finally, the correlation of smaller frontal, temporal, and occipital regions with more recent trauma might inform future therapeutic approaches.
Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers with adulthood war‐related PTSD using structural magnetic resonance imaging and compared them with a validated normative database of more than 2700 healthy individuals.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Armed forces</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>brain morphometry</subject><subject>Canada</subject><subject>Cortex (frontal)</subject><subject>disorder duration</subject><subject>Frontal gyrus</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mental disorders</subject><subject>Military</subject><subject>Military Personnel - psychology</subject><subject>Military psychology</subject><subject>Morphometry</subject><subject>Neuroimaging</subject><subject>Norms</subject><subject>Post traumatic stress disorder</subject><subject>Psychological stress</subject><subject>PTSD</subject><subject>soldiers</subject><subject>Stress Disorders, Post-Traumatic - diagnostic imaging</subject><subject>structural MRI</subject><subject>Temporal lobe</subject><subject>Trauma</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotlY3PoAMuBFham6dNMtSvEFRREVchczMKU2ZmdRkhjI7H8Fn9ElMnerChdkcAh__-c-H0DHBQxLeRdVqPyRcYLGD-kRwGScJo7uoj7EQ8VhS1kMH3i8xJnTMxT7qMS4kSYToo4eXhS3g8_0jddpUUWndamFLqF0bhe9UVzo3uoq8LXIDzkdrUy-ilfV17XRT6tpkka8deB_lxluXgztEe3NdeDjazgF6vrp8mt7Es_vr2-lkFmdsFGolHBjhHGhKMXDO9TwdixR0Nt90pJzmOKdjIqVgKcNJyrHUnEkCCaWap5IN0FmXu3L2rQFfq9L4DIpCV2Abr-hIynA_FSygp3_QpW1cFdopmrCwJOgigTrvqMxZ7x3M1cqZUrtWEaw2otVGtPoWHeCTbWSTlpD_oj9mA0A6YG0KaP-JUnevk8cu9Av_mIkm</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Roy, Olivier</creator><creator>Levasseur‐Moreau, Jean</creator><creator>Renauld, Emmanuelle</creator><creator>Hébert, Luc J.</creator><creator>Leblond, Jean</creator><creator>Bilodeau, Mathieu</creator><creator>Fecteau, Shirley</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4850-0560</orcidid><orcidid>https://orcid.org/0000-0002-9781-4451</orcidid><orcidid>https://orcid.org/0000-0002-4328-7828</orcidid></search><sort><creationdate>202203</creationdate><title>Whole‐brain morphometry in Canadian soldiers with posttraumatic stress disorder</title><author>Roy, Olivier ; Levasseur‐Moreau, Jean ; Renauld, Emmanuelle ; Hébert, Luc J. ; Leblond, Jean ; Bilodeau, Mathieu ; Fecteau, Shirley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3577-64e3144e2b20e444afb87beacf2847242d0d2819973b306b409a4391e622a4b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Armed forces</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>brain morphometry</topic><topic>Canada</topic><topic>Cortex (frontal)</topic><topic>disorder duration</topic><topic>Frontal gyrus</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mental disorders</topic><topic>Military</topic><topic>Military Personnel - psychology</topic><topic>Military psychology</topic><topic>Morphometry</topic><topic>Neuroimaging</topic><topic>Norms</topic><topic>Post traumatic stress disorder</topic><topic>Psychological stress</topic><topic>PTSD</topic><topic>soldiers</topic><topic>Stress Disorders, Post-Traumatic - diagnostic imaging</topic><topic>structural MRI</topic><topic>Temporal lobe</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roy, Olivier</creatorcontrib><creatorcontrib>Levasseur‐Moreau, Jean</creatorcontrib><creatorcontrib>Renauld, Emmanuelle</creatorcontrib><creatorcontrib>Hébert, Luc J.</creatorcontrib><creatorcontrib>Leblond, Jean</creatorcontrib><creatorcontrib>Bilodeau, Mathieu</creatorcontrib><creatorcontrib>Fecteau, Shirley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roy, Olivier</au><au>Levasseur‐Moreau, Jean</au><au>Renauld, Emmanuelle</au><au>Hébert, Luc J.</au><au>Leblond, Jean</au><au>Bilodeau, Mathieu</au><au>Fecteau, Shirley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole‐brain morphometry in Canadian soldiers with posttraumatic stress disorder</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2022-03</date><risdate>2022</risdate><volume>1509</volume><issue>1</issue><spage>37</spage><epage>49</epage><pages>37-49</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces with adulthood war‐related PTSD using structural magnetic resonance imaging. We assessed time since trauma, as well as PTSD, depressive, and anxiety symptoms with the Modified PTSD Symptoms Scale, Beck Depression Inventory, and Beck Anxiety Inventory, respectively. Whole‐brain morphometry was extracted with FreeSurfer and compared with a validated normative database of more than 2700 healthy individuals. Volume and thickness from several regions differed from the norms. Frontal regions were smaller and thinner, particularly the superior and rostral middle frontal gyri. Furthermore, smaller left rostral middle frontal gyrus, left pericalcarine cortex, and right fusiform gyrus were associated with more recent trauma. All subcortical structures were bigger, except the hippocampus. These findings suggest a particular brain morphometric signature of PTSD in soldiers. Smaller and thinner frontal and larger subcortical regions support impaired top‐down and/or downregulation of emotional response in PTSD. Finally, the correlation of smaller frontal, temporal, and occipital regions with more recent trauma might inform future therapeutic approaches.
Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers with adulthood war‐related PTSD using structural magnetic resonance imaging and compared them with a validated normative database of more than 2700 healthy individuals.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34791677</pmid><doi>10.1111/nyas.14707</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4850-0560</orcidid><orcidid>https://orcid.org/0000-0002-9781-4451</orcidid><orcidid>https://orcid.org/0000-0002-4328-7828</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Anxiety Armed forces Brain Brain - diagnostic imaging Brain - pathology brain morphometry Canada Cortex (frontal) disorder duration Frontal gyrus Humans Magnetic Resonance Imaging Mental disorders Military Military Personnel - psychology Military psychology Morphometry Neuroimaging Norms Post traumatic stress disorder Psychological stress PTSD soldiers Stress Disorders, Post-Traumatic - diagnostic imaging structural MRI Temporal lobe Trauma |
| title | Whole‐brain morphometry in Canadian soldiers with posttraumatic stress disorder |
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