Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects

Abstract STUDY QUESTION Can whole-exome sequencing (WES) and in vitro validation studies identify new causative genes associated with teratozoospermia, particularly for sperm head defect? SUMMARY ANSWER We investigated a core group of infertile patients, including 82 cases with unexplained abnormal...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Human reproduction (Oxford) 2021-12, Vol.37 (1), p.152-177
Hauptverfasser:	Li, Yaqian, Wang, Yan, Wen, Yuting, Zhang, Tao, Wang, Xiaodong, Jiang, Chuan, Zheng, Rui, Zhou, Fan, Chen, Daijuan, Yang, Yihong, Shen, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome Animals Argonaute Proteins Cohort Studies Humans Male Mice Repressor Proteins - genetics Sperm Tail Teratozoospermia - genetics Whole Exome Sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!