Weighted Linear Regression Improves Accuracy of Quantitative Elemental Bioimaging by Means of LA-ICP-MS

The application of ordinary least squares (OLS) linear regression is widely used in order to approximate linear external calibration data. However, the assumption of homoscedasticity is often not considered as a requirement for correct data approximation, which can result in a poor regression fit th...

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Veröffentlicht in:	Analytical chemistry (Washington) 2021-11, Vol.93 (47), p.15720-15727
Hauptverfasser:	Funke, Sabrina K. I, Sperling, Michael, Karst, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Calibration Chemistry Empirical analysis Goodness of fit Inductively coupled plasma mass spectrometry Laser ablation Laser Therapy Least squares Least-Squares Analysis Linear Models Mass spectrometry Mass spectroscopy Mathematical analysis Medical imaging Regression analysis Regression models Spectrum Analysis Weighting
Online-Zugang:	Volltext
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