Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review

Acetaminophen (paracetamol, APAP) poisoning is a prominent global cause of drug-induced liver injury. While N-acetylcysteine (NAC) is an effective antidote, it has therapeutic limitations in massive overdose or delayed presentation. The objective is to comprehensively review the literature on fomepi...

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Veröffentlicht in:	Toxicology letters 2022-02, Vol.355, p.47-61
Hauptverfasser:	Pourbagher-Shahri, Ali Mohammad, Schimmel, Jonathan, Shirazi, Farshad M., Nakhaee, Samaneh, Mehrpour, Omid
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Methylpyrazole Acetaminophen Acetaminophen - toxicity Antidotes - therapeutic use Chemical and Drug Induced Liver Injury - drug therapy CYP2E1 Fomepizole Fomepizole - therapeutic use Hepatotoxicity Humans NAC
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