MiR-296-3p inhibits cell proliferation by the SOX4-Wnt/β-catenin pathway in triple-negative breast cancer
MicroRNAs (miRNAs) have been demonstrated to play critical roles in the tumorigenesis of triple-negative breast cancer (TNBC). In this work, we addressed the sepecific role of miR-296-3p in TNBC. The levels of miR-296-3p and SOX4 were determined using RT-qPCR. The function of miR-296-3p overexpressi...
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| Veröffentlicht in: | Journal of biosciences 2021-12, Vol.46 (4), Article 98 |
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| description | MicroRNAs (miRNAs) have been demonstrated to play critical roles in the tumorigenesis of triple-negative breast cancer (TNBC). In this work, we addressed the sepecific role of miR-296-3p in TNBC. The levels of miR-296-3p and SOX4 were determined using RT-qPCR. The function of miR-296-3p overexpression on TNBC cell proliferation, migration, invasion, cancer stem cell (CSC)-like proterties, and Wnt pathway activation was investigated by MTT, EdU, wound healing, Transwell, sphere formation assays and western blot. Mechanistic investigations, including luciferase reporter, RNA pull-down, and RIP assays, were conducted to explore the regulatory mechanisms of miR-296-3p. We found that miR-296-3p was downregulated in TNBC tissues and cells. Overexpression of miR-296-3p suppressed TNBC cell proliferation, migration, invasion, and CSC-like proterties. Furthermore, miR-296-3p could bind to SOX4 and negatively modulate SOX4 expression. In addition, miR-296-3p was verified to inhibit Wnt/β-catenin pathway by downregulating SOX4. Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR-296-3p upregulation-mediated suppressive effect on cellular processes in TNBC. In conclusion, miR‑296‑3p inhibits Wnt/β-catenin pathway by targeting SOX4 and exerts anti-tumor effects in TNBC. |
| doi_str_mv | 10.1007/s12038-021-00219-6 |
| format | Article |
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In this work, we addressed the sepecific role of miR-296-3p in TNBC. The levels of miR-296-3p and SOX4 were determined using RT-qPCR. The function of miR-296-3p overexpression on TNBC cell proliferation, migration, invasion, cancer stem cell (CSC)-like proterties, and Wnt pathway activation was investigated by MTT, EdU, wound healing, Transwell, sphere formation assays and western blot. Mechanistic investigations, including luciferase reporter, RNA pull-down, and RIP assays, were conducted to explore the regulatory mechanisms of miR-296-3p. We found that miR-296-3p was downregulated in TNBC tissues and cells. Overexpression of miR-296-3p suppressed TNBC cell proliferation, migration, invasion, and CSC-like proterties. Furthermore, miR-296-3p could bind to SOX4 and negatively modulate SOX4 expression. In addition, miR-296-3p was verified to inhibit Wnt/β-catenin pathway by downregulating SOX4. Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR-296-3p upregulation-mediated suppressive effect on cellular processes in TNBC. In conclusion, miR‑296‑3p inhibits Wnt/β-catenin pathway by targeting SOX4 and exerts anti-tumor effects in TNBC.</description><identifier>ISSN: 0250-5991</identifier><identifier>ISSN: 0973-7138</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/s12038-021-00219-6</identifier><identifier>PMID: 34785625</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adult ; Anticancer properties ; beta Catenin - genetics ; beta Catenin - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Cancer ; Cell Biology ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement ; Cell proliferation ; Cell Proliferation - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Life Sciences ; Metabolic Networks and Pathways - genetics ; Microbiology ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Neoplasms ; Plant Sciences ; Proliferation ; Regulatory mechanisms (biology) ; SOXC Transcription Factors - genetics ; SOXC Transcription Factors - metabolism ; Stem cells ; Triple Negative Breast Neoplasms - genetics ; Triple Negative Breast Neoplasms - metabolism ; Triple Negative Breast Neoplasms - pathology ; Tumorigenesis ; Wnt protein ; Wnt Signaling Pathway ; Wound healing ; Zoology ; β-Catenin</subject><ispartof>Journal of biosciences, 2021-12, Vol.46 (4), Article 98</ispartof><rights>Indian Academy of Sciences 2021</rights><rights>Indian Academy of Sciences 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-575b8db990e1687d37eeb0cfc718a4c3c953391b54da067a5d2dff7850f326983</citedby><cites>FETCH-LOGICAL-c375t-575b8db990e1687d37eeb0cfc718a4c3c953391b54da067a5d2dff7850f326983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12038-021-00219-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12038-021-00219-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34785625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Duo</creatorcontrib><creatorcontrib>Luo, Laifu</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Qiao, Jian</creatorcontrib><title>MiR-296-3p inhibits cell proliferation by the SOX4-Wnt/β-catenin pathway in triple-negative breast cancer</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><addtitle>J Biosci</addtitle><description>MicroRNAs (miRNAs) have been demonstrated to play critical roles in the tumorigenesis of triple-negative breast cancer (TNBC). In this work, we addressed the sepecific role of miR-296-3p in TNBC. The levels of miR-296-3p and SOX4 were determined using RT-qPCR. The function of miR-296-3p overexpression on TNBC cell proliferation, migration, invasion, cancer stem cell (CSC)-like proterties, and Wnt pathway activation was investigated by MTT, EdU, wound healing, Transwell, sphere formation assays and western blot. Mechanistic investigations, including luciferase reporter, RNA pull-down, and RIP assays, were conducted to explore the regulatory mechanisms of miR-296-3p. We found that miR-296-3p was downregulated in TNBC tissues and cells. Overexpression of miR-296-3p suppressed TNBC cell proliferation, migration, invasion, and CSC-like proterties. Furthermore, miR-296-3p could bind to SOX4 and negatively modulate SOX4 expression. In addition, miR-296-3p was verified to inhibit Wnt/β-catenin pathway by downregulating SOX4. Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR-296-3p upregulation-mediated suppressive effect on cellular processes in TNBC. In conclusion, miR‑296‑3p inhibits Wnt/β-catenin pathway by targeting SOX4 and exerts anti-tumor effects in TNBC.</description><subject>Adult</subject><subject>Anticancer properties</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Metabolic Networks and Pathways - genetics</subject><subject>Microbiology</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Neoplasms</subject><subject>Plant Sciences</subject><subject>Proliferation</subject><subject>Regulatory mechanisms (biology)</subject><subject>SOXC Transcription Factors - genetics</subject><subject>SOXC Transcription Factors - metabolism</subject><subject>Stem cells</subject><subject>Triple Negative Breast Neoplasms - genetics</subject><subject>Triple Negative Breast Neoplasms - metabolism</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><subject>Tumorigenesis</subject><subject>Wnt protein</subject><subject>Wnt Signaling Pathway</subject><subject>Wound healing</subject><subject>Zoology</subject><subject>β-Catenin</subject><issn>0250-5991</issn><issn>0973-7138</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc9OHSEYxYlpo9b2BVwYkm7cUPkzDLBsjP2T2Ji0mnZHGOYbLzdzmRG4Nfe1-iB9Jrm91iYuugESfud8HA5Cx4y-Y5Sqs8w4FZpQzgitiyHtHjqkRgmimNAv6plLSqQx7AC9ynlJKTONoPvoQDRKy5bLQ7T8Er4SbloiZhziInShZOxhHPGcpjEMkFwJU8TdBpcF4G9XPxryPZaz37-IdwViiHh2ZXHvNlWOSwrzCCTCbVX9BNwlcLlg76KH9Bq9HNyY4c3jfoRuPlxcn38il1cfP5-_vyReKFmIVLLTfWcMBdZq1QsF0FE_eMW0a7zwRgphWCeb3tFWOdnzfhhqHjoI3hotjtDpzrcmuFtDLnYV8jaSizCts-XSaCm00qKib5-hy2mdYn3dlmo1axouK8V3lE9TzgkGO6ewcmljGbXbJuyuCVtLsH-asG0VnTxar7sV9E-Sv19fAbEDcr2Kt5D-zf6P7QPPdJL6</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Tian, Duo</creator><creator>Luo, Laifu</creator><creator>Wang, Tao</creator><creator>Qiao, Jian</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>MiR-296-3p inhibits cell proliferation by the SOX4-Wnt/β-catenin pathway in triple-negative breast cancer</title><author>Tian, Duo ; Luo, Laifu ; Wang, Tao ; Qiao, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-575b8db990e1687d37eeb0cfc718a4c3c953391b54da067a5d2dff7850f326983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Anticancer properties</topic><topic>beta Catenin - 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metabolism</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><topic>Tumorigenesis</topic><topic>Wnt protein</topic><topic>Wnt Signaling Pathway</topic><topic>Wound healing</topic><topic>Zoology</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Duo</creatorcontrib><creatorcontrib>Luo, Laifu</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Qiao, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Duo</au><au>Luo, Laifu</au><au>Wang, Tao</au><au>Qiao, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-296-3p inhibits cell proliferation by the SOX4-Wnt/β-catenin pathway in triple-negative breast cancer</atitle><jtitle>Journal of biosciences</jtitle><stitle>J Biosci</stitle><addtitle>J Biosci</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>46</volume><issue>4</issue><artnum>98</artnum><issn>0250-5991</issn><issn>0973-7138</issn><eissn>0973-7138</eissn><abstract>MicroRNAs (miRNAs) have been demonstrated to play critical roles in the tumorigenesis of triple-negative breast cancer (TNBC). In this work, we addressed the sepecific role of miR-296-3p in TNBC. The levels of miR-296-3p and SOX4 were determined using RT-qPCR. The function of miR-296-3p overexpression on TNBC cell proliferation, migration, invasion, cancer stem cell (CSC)-like proterties, and Wnt pathway activation was investigated by MTT, EdU, wound healing, Transwell, sphere formation assays and western blot. Mechanistic investigations, including luciferase reporter, RNA pull-down, and RIP assays, were conducted to explore the regulatory mechanisms of miR-296-3p. We found that miR-296-3p was downregulated in TNBC tissues and cells. Overexpression of miR-296-3p suppressed TNBC cell proliferation, migration, invasion, and CSC-like proterties. Furthermore, miR-296-3p could bind to SOX4 and negatively modulate SOX4 expression. In addition, miR-296-3p was verified to inhibit Wnt/β-catenin pathway by downregulating SOX4. Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR-296-3p upregulation-mediated suppressive effect on cellular processes in TNBC. In conclusion, miR‑296‑3p inhibits Wnt/β-catenin pathway by targeting SOX4 and exerts anti-tumor effects in TNBC.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>34785625</pmid><doi>10.1007/s12038-021-00219-6</doi></addata></record> |
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| subjects | Adult Anticancer properties beta Catenin - genetics beta Catenin - metabolism Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cell Biology Cell growth Cell Line, Tumor Cell migration Cell Movement Cell proliferation Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Humans Life Sciences Metabolic Networks and Pathways - genetics Microbiology MicroRNAs - genetics Middle Aged miRNA Neoplasms Plant Sciences Proliferation Regulatory mechanisms (biology) SOXC Transcription Factors - genetics SOXC Transcription Factors - metabolism Stem cells Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumorigenesis Wnt protein Wnt Signaling Pathway Wound healing Zoology β-Catenin |
| title | MiR-296-3p inhibits cell proliferation by the SOX4-Wnt/β-catenin pathway in triple-negative breast cancer |
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