Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal

Dioscin exhibits neuroprotection in diabetes cognitive dysfunction models via suppression of P2X7R/NLRP3 axis. [Display omitted] •Dioscin presented a clearly protective effect on diabetes cognitive dysfunction via a methylglyoxal-treated PC12 cell model and streptozocin (STZ)-induced rat models.•Dio...

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Veröffentlicht in:	International immunopharmacology 2021-12, Vol.101 (Pt B), p.108314-108314, Article 108314
Hauptverfasser:	Lu, Zhi, Yao, Yiqun, Wang, Jinhong, Peng, J.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Cognitive ability Cognitive Dysfunction Diabetes Diabetes cognitive dysfunction Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Dioscin Diosgenin - analogs & derivatives Disease Models, Animal Inflammasome signal Inflammasomes Inflammasomes - metabolism Inhibition (psychology) Interleukin-1beta - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 P2X7R Pharmacology Pheochromocytoma cells Pyruvaldehyde Rats Receptors, Purinergic P2X7 - metabolism Signal Transduction Streptozocin
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