Genomic evidence for stability of the Bacillus Calmette‐Guérin (BCG) vaccine strain (Pasteur 1173P2) from different batches in Iran

Aims Investigate the genetic stability of the BCG vaccine produced in Iran from different batches compared to the reference strain. Methods and results We comparatively analyzed the whole genome sequences of the vaccine batches from different years. Eleven vials of different batches from 2010, 2018,...

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Veröffentlicht in:	Journal of applied microbiology 2022-03, Vol.132 (3), p.2379-2388
Hauptverfasser:	Asadian, Mahla, Safarchi, Azadeh, Hassanzadeh, Seyed Mehdi, Yaseri, Mehdi, Douraghi, Masoumeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Antibiotics Bacillus Calmette‐Guérin batches BCG Vaccine CRISPR Gene sequencing Genetic diversity genetic stability genetic variations Genomes Genomics Immunization Iran Mycobacterium bovis - genetics Nucleotides Sequence Analysis, DNA Single-nucleotide polymorphism Stability Vaccines
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