Design of a Spiropyran-Based Smart Adsorbent with Dual Response: Focusing on Highly Efficient Enrichment of Phosphopeptides
Smart responsive materials have attractive application prospects due to their tunable behaviors. In this work, we design novel spiropyran (SP)-based magnetic nanoparticles (MNP-SP) with dual response to ultraviolet light and pH and apply them to the enrichment of phosphopeptides. SP is modified on t...
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| Veröffentlicht in: | ACS applied materials & interfaces 2021-12, Vol.13 (47), p.55806-55814 |
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| container_issue | 47 |
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| container_title | ACS applied materials & interfaces |
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| creator | Zhao, Yanqing Li, Zheng Ma, Jiutong Jia, Qiong |
| description | Smart responsive materials have attractive application prospects due to their tunable behaviors. In this work, we design novel spiropyran (SP)-based magnetic nanoparticles (MNP-SP) with dual response to ultraviolet light and pH and apply them to the enrichment of phosphopeptides. SP is modified on the surface of magnetic nanoparticles through a simple esterification reaction, based on which an MNP-SP-MS phosphopeptide identification platform is established. The capture and release of phosphopeptides are facilely adjusted by changing external light and the pH of the solution. The smart responsive MNP-SP has fast magnetic response performance, high sensitivity (detection limit of 0.4 fmol), and good reusability (6 cycles). In addition, MNP-SP is used for the enrichment of phosphopeptides in skimmed milk, human saliva, and human serum samples, indicating that it is an ideal adsorbent for enriching low-abundance phosphopeptides in complex biological environments. |
| doi_str_mv | 10.1021/acsami.1c14739 |
| format | Article |
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Mater. Interfaces</addtitle><description>Smart responsive materials have attractive application prospects due to their tunable behaviors. In this work, we design novel spiropyran (SP)-based magnetic nanoparticles (MNP-SP) with dual response to ultraviolet light and pH and apply them to the enrichment of phosphopeptides. SP is modified on the surface of magnetic nanoparticles through a simple esterification reaction, based on which an MNP-SP-MS phosphopeptide identification platform is established. The capture and release of phosphopeptides are facilely adjusted by changing external light and the pH of the solution. The smart responsive MNP-SP has fast magnetic response performance, high sensitivity (detection limit of 0.4 fmol), and good reusability (6 cycles). In addition, MNP-SP is used for the enrichment of phosphopeptides in skimmed milk, human saliva, and human serum samples, indicating that it is an ideal adsorbent for enriching low-abundance phosphopeptides in complex biological environments.</description><subject>Adsorption</subject><subject>Animals</subject><subject>Benzopyrans - chemical synthesis</subject><subject>Benzopyrans - chemistry</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Cattle</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indoles - chemical synthesis</subject><subject>Indoles - chemistry</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Milk - chemistry</subject><subject>Molecular Structure</subject><subject>Nitro Compounds - chemical synthesis</subject><subject>Nitro Compounds - chemistry</subject><subject>Particle Size</subject><subject>Phosphopeptides - chemistry</subject><subject>Surface Properties</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtP3DAURi1UBJR2yxJ5WSFl6kee7HgMpRISCNp15LGvJ0aJHXwToVH_fD2aKbuufGWd77u6h5AzzhacCf5daVSDW3DN80o2B-SEN3me1aIQnz7mPD8mnxFfGSulYMUROZZ5VZdNLk_In1tAt_Y0WKroy-hiGDdR-exaIRj6Mqg40SuDIa7AT_TdTR29nVVPnwHH4BEu6V3QMzq_psHTe7fu-g1dWuu02waWPjrdDdsxbXjqAo5dGGGcnAH8Qg6t6hG-7t9T8vtu-evmPnt4_PHz5uohU1KyKasUt7YWQmthxAqaBoRSpamMrQoh6nqVPmQpLJNVYWojlKm0BZPOhlyyspSn5Nuud4zhbQac2sGhhr5XHsKMrSiaupA1lyKhix2qY0CMYNsxuiRh03LWboW3O-HtXngKnO-759UA5gP_ZzgBFzsgBdvXMEefTv1f219NLIy3</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Zhao, Yanqing</creator><creator>Li, Zheng</creator><creator>Ma, Jiutong</creator><creator>Jia, Qiong</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3799-0576</orcidid></search><sort><creationdate>20211201</creationdate><title>Design of a Spiropyran-Based Smart Adsorbent with Dual Response: Focusing on Highly Efficient Enrichment of Phosphopeptides</title><author>Zhao, Yanqing ; Li, Zheng ; Ma, Jiutong ; Jia, Qiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-7a1ff822cc2d2be99e2aa6d7df752288b9e2362f0375d8d2ad7cfed244e430663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adsorption</topic><topic>Animals</topic><topic>Benzopyrans - chemical synthesis</topic><topic>Benzopyrans - chemistry</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Cattle</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - chemistry</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Milk - chemistry</topic><topic>Molecular Structure</topic><topic>Nitro Compounds - chemical synthesis</topic><topic>Nitro Compounds - chemistry</topic><topic>Particle Size</topic><topic>Phosphopeptides - chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yanqing</creatorcontrib><creatorcontrib>Li, Zheng</creatorcontrib><creatorcontrib>Ma, Jiutong</creatorcontrib><creatorcontrib>Jia, Qiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yanqing</au><au>Li, Zheng</au><au>Ma, Jiutong</au><au>Jia, Qiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design of a Spiropyran-Based Smart Adsorbent with Dual Response: Focusing on Highly Efficient Enrichment of Phosphopeptides</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>13</volume><issue>47</issue><spage>55806</spage><epage>55814</epage><pages>55806-55814</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Smart responsive materials have attractive application prospects due to their tunable behaviors. In this work, we design novel spiropyran (SP)-based magnetic nanoparticles (MNP-SP) with dual response to ultraviolet light and pH and apply them to the enrichment of phosphopeptides. SP is modified on the surface of magnetic nanoparticles through a simple esterification reaction, based on which an MNP-SP-MS phosphopeptide identification platform is established. The capture and release of phosphopeptides are facilely adjusted by changing external light and the pH of the solution. The smart responsive MNP-SP has fast magnetic response performance, high sensitivity (detection limit of 0.4 fmol), and good reusability (6 cycles). 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| subjects | Adsorption Animals Benzopyrans - chemical synthesis Benzopyrans - chemistry Biological and Medical Applications of Materials and Interfaces Cattle Humans Hydrogen-Ion Concentration Indoles - chemical synthesis Indoles - chemistry Magnetite Nanoparticles - chemistry Milk - chemistry Molecular Structure Nitro Compounds - chemical synthesis Nitro Compounds - chemistry Particle Size Phosphopeptides - chemistry Surface Properties |
| title | Design of a Spiropyran-Based Smart Adsorbent with Dual Response: Focusing on Highly Efficient Enrichment of Phosphopeptides |
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