Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae)
The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M....
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| Veröffentlicht in: | Chemistry & biodiversity 2021-12, Vol.18 (12), p.e2100653-n/a |
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| creator | El Yaagoubi, Mohamed Mechqoq, Hicham Ortiz, Sergio Cavaleiro, Carlos Lecsö‐Bornet, Marylin Pereira, Catarina Guerreiro Rodrigues, Maria João Custódio, Luísa El Mousadik, Abdelhamid Picot, Laurent Kritsanida, Marina Msanda, Fouad El Aouad, Noureddine Grougnet, Raphaël |
| description | The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index |
| doi_str_mv | 10.1002/cbdv.202100653 |
| format | Article |
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Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100 μg/mL.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202100653</identifier><identifier>PMID: 34786843</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antibacterial activity ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; biological activities ; Borneol ; Camphor ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chemical composition ; Cytotoxicity ; Drug Screening Assays, Antitumor ; Endemic species ; essential oil ; Essential oils ; Humans ; Lamiaceae ; Lamiaceae - chemistry ; M. arganietorum ; Melanoma ; Metabolites ; Mice ; Micromeria ; Micromeria macrosiphon ; Oils, Volatile - chemistry ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Pinene ; Selectivity ; Terpinene ; Toxicity ; Tumor cell lines ; Tumors</subject><ispartof>Chemistry & biodiversity, 2021-12, Vol.18 (12), p.e2100653-n/a</ispartof><rights>2021 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2021 Wiley-VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4013-dece1077fb1f35437a41d75a1f1013fc371cf38cc5c6fc5fe00b54c985ecf9a53</citedby><cites>FETCH-LOGICAL-c4013-dece1077fb1f35437a41d75a1f1013fc371cf38cc5c6fc5fe00b54c985ecf9a53</cites><orcidid>0000-0003-1657-2997</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202100653$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202100653$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34786843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Yaagoubi, Mohamed</creatorcontrib><creatorcontrib>Mechqoq, Hicham</creatorcontrib><creatorcontrib>Ortiz, Sergio</creatorcontrib><creatorcontrib>Cavaleiro, Carlos</creatorcontrib><creatorcontrib>Lecsö‐Bornet, Marylin</creatorcontrib><creatorcontrib>Pereira, Catarina Guerreiro</creatorcontrib><creatorcontrib>Rodrigues, Maria João</creatorcontrib><creatorcontrib>Custódio, Luísa</creatorcontrib><creatorcontrib>El Mousadik, Abdelhamid</creatorcontrib><creatorcontrib>Picot, Laurent</creatorcontrib><creatorcontrib>Kritsanida, Marina</creatorcontrib><creatorcontrib>Msanda, Fouad</creatorcontrib><creatorcontrib>El Aouad, Noureddine</creatorcontrib><creatorcontrib>Grougnet, Raphaël</creatorcontrib><title>Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae)</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100 μg/mL.</description><subject>Animals</subject><subject>Antibacterial activity</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>biological activities</subject><subject>Borneol</subject><subject>Camphor</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chemical composition</subject><subject>Cytotoxicity</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Endemic species</subject><subject>essential oil</subject><subject>Essential oils</subject><subject>Humans</subject><subject>Lamiaceae</subject><subject>Lamiaceae - chemistry</subject><subject>M. arganietorum</subject><subject>Melanoma</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Micromeria</subject><subject>Micromeria macrosiphon</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - isolation & purification</subject><subject>Oils, Volatile - pharmacology</subject><subject>Pinene</subject><subject>Selectivity</subject><subject>Terpinene</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEURi1ExatsWSJLbGCR1I_xjLOEKaWVglj0sbUcz3ViNB4HewbEov-9HpIGqZuufH3v8ZHtD6EzSqaUEPbJLJrnKSMsb0rB99ARLSmbUCnJ_q6u2CE6Tukx87kvD9AhLypZyoIfod_1CrwzusV18OuQXO9Ch3XX4BsX2rB8G303EaBz3RIHi_sV4NuUoOtdHj24No3de2di8BCdxl7nMrn1aiu6n2Idl7pz0Ic4eHw5195pAxquPqIPVrcJTrfrCfr55fZH_XUyf7j7Vl_PJ6YglE8aMEBJVdkFtVwUvNIFbSqhqaV5bA2vqLFcGiNMaY2wQMhCFGYmBRg704KfoMuNdx3D0wCpV94lA22rOwhDUkxkNn9KKTN68Q_6GIbY5dspVlLJGK2KUTjdUONTUwSr1tF5HV8VJWoMRo3BqF0w-cD5VjssPDQ7_G8SGZhtgBfXwut_dKq--fzrXf4HirGapA</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>El Yaagoubi, Mohamed</creator><creator>Mechqoq, Hicham</creator><creator>Ortiz, Sergio</creator><creator>Cavaleiro, Carlos</creator><creator>Lecsö‐Bornet, Marylin</creator><creator>Pereira, Catarina Guerreiro</creator><creator>Rodrigues, Maria João</creator><creator>Custódio, Luísa</creator><creator>El Mousadik, Abdelhamid</creator><creator>Picot, Laurent</creator><creator>Kritsanida, Marina</creator><creator>Msanda, Fouad</creator><creator>El Aouad, Noureddine</creator><creator>Grougnet, Raphaël</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1657-2997</orcidid></search><sort><creationdate>202112</creationdate><title>Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae)</title><author>El Yaagoubi, Mohamed ; 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Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. 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| subjects | Animals Antibacterial activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology biological activities Borneol Camphor Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemical composition Cytotoxicity Drug Screening Assays, Antitumor Endemic species essential oil Essential oils Humans Lamiaceae Lamiaceae - chemistry M. arganietorum Melanoma Metabolites Mice Micromeria Micromeria macrosiphon Oils, Volatile - chemistry Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Pinene Selectivity Terpinene Toxicity Tumor cell lines Tumors |
| title | Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae) |
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