Urine Proteomics and Renal Single‐Cell Transcriptomics Implicate Interleukin‐16 in Lupus Nephritis

Objective Current lupus nephritis (LN) treatments are effective in only 30% of patients, emphasizing the need for novel therapeutic strategies. We undertook this study to develop mechanistic hypotheses and explore novel biomarkers by analyzing the longitudinal urinary proteomic profiles in LN patien...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2022-05, Vol.74 (5), p.829-839
Hauptverfasser:	Fava, Andrea, Rao, Deepak A., Mohan, Chandra, Zhang, Ting, Rosenberg, Avi, Fenaroli, Paride, Belmont, H. Michael, Izmirly, Peter, Clancy, Robert, Trujillo, Jose Monroy, Fine, Derek, Arazi, Arnon, Berthier, Celine C., Davidson, Anne, James, Judith A., Diamond, Betty, Hacohen, Nir, Wofsy, David, Raychaudhuri, Soumya, Apruzzese, William, Buyon, Jill, Petri, Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products Biomarkers Biomarkers - metabolism Biomonitoring Biopsy CD163 antigen CD4 antigen Cell activation Chemotaxis Chronic conditions Cytokines Degranulation Extracellular matrix Female Gene sequencing Growth factors Humans Immune system Inflammation Interleukin 1 Interleukin 16 Interleukin-16 - genetics Interleukin-16 - metabolism Interleukins Kidney - pathology Kidneys Leukocytes (neutrophilic) Lupus Lupus nephritis Lupus Nephritis - pathology Male Nephritis Pathogenesis Patients Proteins Proteomes Proteomics Proteomics - methods Single-Cell Analysis Systemic lupus erythematosus Transcriptome Transcriptomics Transforming growth factor-b Urine
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