TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway

Hyperglycemia-induced oxidative stress in podocytes exerts a major role in the pathological process of diabetic nephropathy. Tripartite motif-containing protein 32 (TRIM32) has been reported to be a key protein in the modulation of cellular apoptosis and oxidative stress under various pathological p...

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Veröffentlicht in:	Inflammation 2022-06, Vol.45 (3), p.992-1006
Hauptverfasser:	Chen, Zhao, Tian, Lifang, Wang, Li, Ma, Xiaotao, Lei, Fuqian, Chen, Xianghui, Fu, Rongguo
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Apoptosis Biomedical and Life Sciences Biomedicine Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetic Nephropathies - metabolism Diabetic nephropathy Female Glucose - metabolism Glucose - toxicity Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - metabolism Humans Hyperglycemia Immunology Inflammation Internal Medicine Kinases Male Mice Nephropathy NF-E2-Related Factor 2 - metabolism Original Article Oxidative stress Oxidative Stress - physiology Pathology Pharmacology/Toxicology Podocytes - metabolism Proto-Oncogene Proteins c-akt - metabolism Rheumatology Transcription Factors - metabolism Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases
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