Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1–42 through Nrf2/HO-1 and NF-κB signaling pathway in mice

•Inhibition of GPR17 with cangrelor ameliorates cognitive impairment and synaptic deficits induced by Aβ1–42 in mice.•Exposure to Aβ1–42 leads to increased expression of GPR17 in the brain.•The neuroprotective effects of cangrelor may be mediated by Nrf2/HO-1 and NF-κB signaling pathways. The accumu...

Ausführliche Beschreibung