Biofabrication of small diameter tissue-engineered vascular grafts
Current clinical treatment strategies for the bypassing of small diameter (
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| Veröffentlicht in: | Acta biomaterialia 2022-01, Vol.138, p.92-111 |
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| creator | Weekes, Angus Bartnikowski, Nicole Pinto, Nigel Jenkins, Jason Meinert, Christoph Klein, Travis J. |
| description | Current clinical treatment strategies for the bypassing of small diameter ( |
| doi_str_mv | 10.1016/j.actbio.2021.11.012 |
| format | Article |
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Current clinical strategies for the management of cardiovascular disease using small diameter vessel bypassing procedures are inadequate, with up to 75% of synthetic grafts failing within 3 years of implantation. It is this critically important clinical problem that researchers in the field of vascular tissue engineering and regenerative medicine aim to alleviate using biofabrication methods combining additive manufacturing, biomaterials science and advanced cellular biology. While many approaches facilitate the development of bioengineered constructs which mimic the structure and function of native blood vessels, several challenges must still be overcome for clinical translation of the next generation of tissue-engineered vascular grafts.
[Display omitted]</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2021.11.012</identifier><identifier>PMID: 34781026</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>3-D printers ; Additive manufacturing ; Autografts ; Biocompatible Materials ; Bioengineering ; Biofabrication ; Biomaterials ; Biomechanics ; Biomedical materials ; Biomimetics ; Bioprinting ; Blood Vessel Prosthesis ; Blood vessels ; Cardiovascular disease ; Cardiovascular diseases ; Disease management ; Grafting ; Humans ; Hyperplasia ; Manufacturing ; Medicine ; Printing, Three-Dimensional ; Production methods ; Regenerative medicine ; State-of-the-art reviews ; Structure-function relationships ; Surgical implants ; Three dimensional printing ; Thromboembolism ; Thrombosis ; Tissue Engineering ; Tissue Scaffolds ; Vascular graft bypassing ; Vascular tissue</subject><ispartof>Acta biomaterialia, 2022-01, Vol.138, p.92-111</ispartof><rights>2021 Acta Materialia Inc.</rights><rights>Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Jan 15, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-daf448625933927b186496ada1b452e09e61eb6eec8290a2b79b6e012a9d41253</citedby><cites>FETCH-LOGICAL-c456t-daf448625933927b186496ada1b452e09e61eb6eec8290a2b79b6e012a9d41253</cites><orcidid>0000-0002-9306-2723 ; 0000-0002-6669-7766 ; 0000-0002-9844-5774 ; 0000-0002-7036-4067</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2021.11.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34781026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weekes, Angus</creatorcontrib><creatorcontrib>Bartnikowski, Nicole</creatorcontrib><creatorcontrib>Pinto, Nigel</creatorcontrib><creatorcontrib>Jenkins, Jason</creatorcontrib><creatorcontrib>Meinert, Christoph</creatorcontrib><creatorcontrib>Klein, Travis J.</creatorcontrib><title>Biofabrication of small diameter tissue-engineered vascular grafts</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Current clinical treatment strategies for the bypassing of small diameter (<6 mm) blood vessels in the management of cardiovascular disease frequently fail due to a lack of suitable autologous grafts, as well as infection, thrombosis, and intimal hyperplasia associated with synthetic grafts. The rapid advancement of 3D printing and regenerative medicine technologies enabling the manufacture of biological, tissue-engineered vascular grafts (TEVGs) with the ability to integrate, remodel, and repair in vivo, promises a paradigm shift in cardiovascular disease management. This review comprehensively covers current state-of-the-art biofabrication technologies for the development of biomimetic TEVGs. Various scaffold based additive manufacturing methods used in vascular tissue engineering, including 3D printing, bioprinting, electrospinning and melt electrowriting, are discussed and assessed against the biomechanical and functional requirements of human vasculature, while the efficacy of decellularization protocols currently applied to engineered and native vessels are evaluated. Further, we provide interdisciplinary insight into the outlook of regenerative medicine for the development of vascular grafts, exploring key considerations and perspectives for the successful clinical integration of evolving technologies. It is expected that continued advancements in microscale additive manufacturing, biofabrication, tissue engineering and decellularization will culminate in the development of clinically viable, off-the-shelf TEVGs for small diameter applications in the near future.
Current clinical strategies for the management of cardiovascular disease using small diameter vessel bypassing procedures are inadequate, with up to 75% of synthetic grafts failing within 3 years of implantation. It is this critically important clinical problem that researchers in the field of vascular tissue engineering and regenerative medicine aim to alleviate using biofabrication methods combining additive manufacturing, biomaterials science and advanced cellular biology. While many approaches facilitate the development of bioengineered constructs which mimic the structure and function of native blood vessels, several challenges must still be overcome for clinical translation of the next generation of tissue-engineered vascular grafts.
[Display omitted]</description><subject>3-D printers</subject><subject>Additive manufacturing</subject><subject>Autografts</subject><subject>Biocompatible Materials</subject><subject>Bioengineering</subject><subject>Biofabrication</subject><subject>Biomaterials</subject><subject>Biomechanics</subject><subject>Biomedical materials</subject><subject>Biomimetics</subject><subject>Bioprinting</subject><subject>Blood Vessel Prosthesis</subject><subject>Blood vessels</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Disease management</subject><subject>Grafting</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Manufacturing</subject><subject>Medicine</subject><subject>Printing, Three-Dimensional</subject><subject>Production methods</subject><subject>Regenerative medicine</subject><subject>State-of-the-art reviews</subject><subject>Structure-function relationships</subject><subject>Surgical implants</subject><subject>Three dimensional printing</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><subject>Vascular graft bypassing</subject><subject>Vascular tissue</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMofqz-A5GCFy-tmTRN0oug4hcseNFzSNPpkqVtNGkF_71ZVj148DQZeOadyUPIKdACKIjLdWHs1DhfMMqgACgosB1yCEqqXFZC7aa35CyXVMABOYpxTWmpgKl9clByqYAycUhubpzvTBOcNZPzY-a7LA6m77PWmQEnDNnkYpwxx3HlRsSAbfZhop17E7JVMN0Uj8leZ_qIJ991QV7v715uH_Pl88PT7fUyt7wSU96ajnMlWFWXZc1kA0rwWpjWQMMrhrRGAdgIRKtYTQ1rZJ269ClTtxxYVS7IxTb3Lfj3GeOkBxct9r0Z0c9Rp2RFpSjTggU5_4Ou_RzGdJ1motzkV5Inim8pG3yMATv9FtxgwqcGqjeO9VpvHeuNYw2g0zlp7Ow7fG4GbH-HfqQm4GoLYLLx4TDoaB2OFlsX0E669e7_DV_qc42G</recordid><startdate>20220115</startdate><enddate>20220115</enddate><creator>Weekes, Angus</creator><creator>Bartnikowski, Nicole</creator><creator>Pinto, Nigel</creator><creator>Jenkins, Jason</creator><creator>Meinert, Christoph</creator><creator>Klein, Travis J.</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9306-2723</orcidid><orcidid>https://orcid.org/0000-0002-6669-7766</orcidid><orcidid>https://orcid.org/0000-0002-9844-5774</orcidid><orcidid>https://orcid.org/0000-0002-7036-4067</orcidid></search><sort><creationdate>20220115</creationdate><title>Biofabrication of small diameter tissue-engineered vascular grafts</title><author>Weekes, Angus ; 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The rapid advancement of 3D printing and regenerative medicine technologies enabling the manufacture of biological, tissue-engineered vascular grafts (TEVGs) with the ability to integrate, remodel, and repair in vivo, promises a paradigm shift in cardiovascular disease management. This review comprehensively covers current state-of-the-art biofabrication technologies for the development of biomimetic TEVGs. Various scaffold based additive manufacturing methods used in vascular tissue engineering, including 3D printing, bioprinting, electrospinning and melt electrowriting, are discussed and assessed against the biomechanical and functional requirements of human vasculature, while the efficacy of decellularization protocols currently applied to engineered and native vessels are evaluated. Further, we provide interdisciplinary insight into the outlook of regenerative medicine for the development of vascular grafts, exploring key considerations and perspectives for the successful clinical integration of evolving technologies. It is expected that continued advancements in microscale additive manufacturing, biofabrication, tissue engineering and decellularization will culminate in the development of clinically viable, off-the-shelf TEVGs for small diameter applications in the near future.
Current clinical strategies for the management of cardiovascular disease using small diameter vessel bypassing procedures are inadequate, with up to 75% of synthetic grafts failing within 3 years of implantation. It is this critically important clinical problem that researchers in the field of vascular tissue engineering and regenerative medicine aim to alleviate using biofabrication methods combining additive manufacturing, biomaterials science and advanced cellular biology. While many approaches facilitate the development of bioengineered constructs which mimic the structure and function of native blood vessels, several challenges must still be overcome for clinical translation of the next generation of tissue-engineered vascular grafts.
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| ispartof | Acta biomaterialia, 2022-01, Vol.138, p.92-111 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3-D printers Additive manufacturing Autografts Biocompatible Materials Bioengineering Biofabrication Biomaterials Biomechanics Biomedical materials Biomimetics Bioprinting Blood Vessel Prosthesis Blood vessels Cardiovascular disease Cardiovascular diseases Disease management Grafting Humans Hyperplasia Manufacturing Medicine Printing, Three-Dimensional Production methods Regenerative medicine State-of-the-art reviews Structure-function relationships Surgical implants Three dimensional printing Thromboembolism Thrombosis Tissue Engineering Tissue Scaffolds Vascular graft bypassing Vascular tissue |
| title | Biofabrication of small diameter tissue-engineered vascular grafts |
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