Substrates of human hepatic cytochrome P450 3A4

Cytochrome P450 isozyme 3A4 (CYP3A4) is a major isozyme in the human liver and is known to metabolize a large variety of xenobiotics and endogenous biochemicals. The identities of CYP3A4 substrates are summarized here. A total of 32 chemicals belonging to different structural classes have been evalu...

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Veröffentlicht in:	Toxicology 1995-12, Vol.104 (1), p.1-8
Hauptverfasser:	Li, Albert P., Kaminski, Donald L., Rasmussen, Asenath
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Biotransformation Cells, Cultured Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochrome P450 3A4 Enzyme Induction - drug effects Enzyme Inhibitors - metabolism Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Human drug metabolism Humans Hydroxylation Liver - cytology Liver - drug effects Liver - enzymology Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Oxidation-Reduction Oxidoreductases Structure-Activity Relationship Substrate Specificity Xenobiotics Xenobiotics - metabolism Xenobiotics - toxicity
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