Association of Fetuin-A with Thr256Ser exon polymorphism of α2-Heremans Schmid Glycoprotein (AHSG) gene in type 2 diabetic patients with overt nephropathy
Circulatory Fetuin-A has been well reported to elevate the risk for Diabetic Nephropathy (DN) and is associated with many vascular complications. Compelling reports have well documented that the circulatory levels of Fetuin-A directly have an impact on its AHSG (α2- Heremans- Schmid Glycoprotein) ge...
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| Veröffentlicht in: | Journal of diabetes and its complications 2022-01, Vol.36 (1), p.108074-108074, Article 108074 |
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| container_title | Journal of diabetes and its complications |
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| creator | Umapathy, Dhamodharan Subramanyam, Paridhy Vanniya Krishnamoorthy, Ezhilarasi Viswanathan, Vijay Ramkumar, Kunka Mohanram |
| description | Circulatory Fetuin-A has been well reported to elevate the risk for Diabetic Nephropathy (DN) and is associated with many vascular complications. Compelling reports have well documented that the circulatory levels of Fetuin-A directly have an impact on its AHSG (α2- Heremans- Schmid Glycoprotein) gene single nucleotide polymorphisms (SNP). Thus, in this study among the South Indian T2DM population, we aim to explore the association of AHSG Thr256Ser (rs4918) SNP in subjects with DN and correlate with the circulatory levels of Fetuin-A at various stages of DN patients.
A total of 975 subjects were recruited, such as Group-I, consisting of Controls (n = 300), Group-II, with normoalbuminuria (n = 300), Group-IIIa, with incipient microalbuminuria (n = 195), Group-IIIb, with persistent macroalbuminuria (n = 180)] and were subjected for genotyping using PCR-Restriction Fragment Length Polymorphism (RFLP). Circulatory Fetuin-A was measured using sandwich enzyme-linked immunosorbent assay (ELISA).
The ‘G’ allele of AHSG exon-7 (C/G) SNP is significantly concomitant and conferred significant risk for normoalbuminuria subjects. In the DN subjects, the ‘G' allele showed the risk for persistent macroalbuminuria. A noticeable stepwise decrease was evidenced in the circulatory Fetuin-A among persistent macroalbuminuria over incipient microalbuminuria from normoalbuminuria. Further, the circulatory Fetuin-A was lowered in DN subjects with mutant GG genotype than the wild CC.
AHSG Thr256Ser (rs4918) SNP was associated with renal complications among South Indian T2DM subjects.
•The association of AHSG Thr256Ser (rs4918) SNP in subjects with DN•Correlation of circulatory Fetuin-A at various stages of DN patients.•The circulatory Fetuin-A was found to be lowered in DN subjects with mutant GG genotype than the wild CC.•AHSG Thr256Ser (rs4918) SNP is associated with renal complications among South Indian T2DM subjects |
| doi_str_mv | 10.1016/j.jdiacomp.2021.108074 |
| format | Article |
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A total of 975 subjects were recruited, such as Group-I, consisting of Controls (n = 300), Group-II, with normoalbuminuria (n = 300), Group-IIIa, with incipient microalbuminuria (n = 195), Group-IIIb, with persistent macroalbuminuria (n = 180)] and were subjected for genotyping using PCR-Restriction Fragment Length Polymorphism (RFLP). Circulatory Fetuin-A was measured using sandwich enzyme-linked immunosorbent assay (ELISA).
The ‘G’ allele of AHSG exon-7 (C/G) SNP is significantly concomitant and conferred significant risk for normoalbuminuria subjects. In the DN subjects, the ‘G' allele showed the risk for persistent macroalbuminuria. A noticeable stepwise decrease was evidenced in the circulatory Fetuin-A among persistent macroalbuminuria over incipient microalbuminuria from normoalbuminuria. Further, the circulatory Fetuin-A was lowered in DN subjects with mutant GG genotype than the wild CC.
AHSG Thr256Ser (rs4918) SNP was associated with renal complications among South Indian T2DM subjects.
•The association of AHSG Thr256Ser (rs4918) SNP in subjects with DN•Correlation of circulatory Fetuin-A at various stages of DN patients.•The circulatory Fetuin-A was found to be lowered in DN subjects with mutant GG genotype than the wild CC.•AHSG Thr256Ser (rs4918) SNP is associated with renal complications among South Indian T2DM subjects</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2021.108074</identifier><identifier>PMID: 34774416</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>alpha-2-HS-Glycoprotein - genetics ; alpha-2-HS-Glycoprotein - metabolism ; Calcification ; Cholesterol ; Creatinine ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Nephropathies ; Diabetic nephropathy ; Disease ; Enzymes ; Exons ; Fasting ; Fetuin-A ; Genotype & phenotype ; Glycoproteins ; High density lipoprotein ; Humans ; Insulin resistance ; Mutation ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Proteins ; SNP ; Statistical analysis ; T2DM ; α2-Heremans Schmid glycoprotein (AHSG)</subject><ispartof>Journal of diabetes and its complications, 2022-01, Vol.36 (1), p.108074-108074, Article 108074</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-758e231898a73f5d2110044a25bbd8c0ed598179f17cabcb29e64252f055a6223</citedby><cites>FETCH-LOGICAL-c396t-758e231898a73f5d2110044a25bbd8c0ed598179f17cabcb29e64252f055a6223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2615295714?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34774416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Umapathy, Dhamodharan</creatorcontrib><creatorcontrib>Subramanyam, Paridhy Vanniya</creatorcontrib><creatorcontrib>Krishnamoorthy, Ezhilarasi</creatorcontrib><creatorcontrib>Viswanathan, Vijay</creatorcontrib><creatorcontrib>Ramkumar, Kunka Mohanram</creatorcontrib><title>Association of Fetuin-A with Thr256Ser exon polymorphism of α2-Heremans Schmid Glycoprotein (AHSG) gene in type 2 diabetic patients with overt nephropathy</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>Circulatory Fetuin-A has been well reported to elevate the risk for Diabetic Nephropathy (DN) and is associated with many vascular complications. Compelling reports have well documented that the circulatory levels of Fetuin-A directly have an impact on its AHSG (α2- Heremans- Schmid Glycoprotein) gene single nucleotide polymorphisms (SNP). Thus, in this study among the South Indian T2DM population, we aim to explore the association of AHSG Thr256Ser (rs4918) SNP in subjects with DN and correlate with the circulatory levels of Fetuin-A at various stages of DN patients.
A total of 975 subjects were recruited, such as Group-I, consisting of Controls (n = 300), Group-II, with normoalbuminuria (n = 300), Group-IIIa, with incipient microalbuminuria (n = 195), Group-IIIb, with persistent macroalbuminuria (n = 180)] and were subjected for genotyping using PCR-Restriction Fragment Length Polymorphism (RFLP). Circulatory Fetuin-A was measured using sandwich enzyme-linked immunosorbent assay (ELISA).
The ‘G’ allele of AHSG exon-7 (C/G) SNP is significantly concomitant and conferred significant risk for normoalbuminuria subjects. In the DN subjects, the ‘G' allele showed the risk for persistent macroalbuminuria. A noticeable stepwise decrease was evidenced in the circulatory Fetuin-A among persistent macroalbuminuria over incipient microalbuminuria from normoalbuminuria. Further, the circulatory Fetuin-A was lowered in DN subjects with mutant GG genotype than the wild CC.
AHSG Thr256Ser (rs4918) SNP was associated with renal complications among South Indian T2DM subjects.
•The association of AHSG Thr256Ser (rs4918) SNP in subjects with DN•Correlation of circulatory Fetuin-A at various stages of DN patients.•The circulatory Fetuin-A was found to be lowered in DN subjects with mutant GG genotype than the wild CC.•AHSG Thr256Ser (rs4918) SNP is associated with renal complications among South Indian T2DM subjects</description><subject>alpha-2-HS-Glycoprotein - genetics</subject><subject>alpha-2-HS-Glycoprotein - metabolism</subject><subject>Calcification</subject><subject>Cholesterol</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Nephropathies</subject><subject>Diabetic nephropathy</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Exons</subject><subject>Fasting</subject><subject>Fetuin-A</subject><subject>Genotype & phenotype</subject><subject>Glycoproteins</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Mutation</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Proteins</subject><subject>SNP</subject><subject>Statistical analysis</subject><subject>T2DM</subject><subject>α2-Heremans Schmid glycoprotein (AHSG)</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1u1DAUhSMEoqXwCpUlNmWRqe3EdrJjVNEZpEpdTCt1ZznODXGUxMF2WvIsPAUvwjPhUVoWbFj55373nqtzkuSc4A3BhF92m642Stth2lBMSfwssMhfJaekEFmac_zwOt4x42khqDhJ3nnfYYw5Y-RtcpLlQuQ54afJz633VhsVjB2RbdA1hNmM6RY9mdCiu9ZRxg_gEPyI9cn2y2Dd1Bo_HOHfv2i6BweDGj066HYwNdr1i7aTswHMiC62-8PuE_oGI6D4DMsEiKK4eAXBaDRFWRiDX8XsI7iARphaZ2OlXd4nbxrVe_jwfJ4l99df7q726c3t7uvV9ibVWclDKlgBNCNFWSiRNaymhGCc54qyqqoLjaFmZUFE2RChVaUrWgLPKaMNZkxxSrOz5GKdG9f-PoMPcjBeQ9-rEezsJWWlKHA0Fkf04z9oZ2c3xu0k5YTRkgmSR4qvlHbWeweNnJwZlFskwfIYn-zkS3zyGJ9c44uN58_j52qA-m_bS14R-LwCEP14NOCk19FCDbVxoIOsrfmfxh_UuK9Y</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Umapathy, Dhamodharan</creator><creator>Subramanyam, Paridhy Vanniya</creator><creator>Krishnamoorthy, Ezhilarasi</creator><creator>Viswanathan, Vijay</creator><creator>Ramkumar, Kunka Mohanram</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>Association of Fetuin-A with Thr256Ser exon polymorphism of α2-Heremans Schmid Glycoprotein (AHSG) gene in type 2 diabetic patients with overt nephropathy</title><author>Umapathy, Dhamodharan ; Subramanyam, Paridhy Vanniya ; Krishnamoorthy, Ezhilarasi ; Viswanathan, Vijay ; Ramkumar, Kunka Mohanram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-758e231898a73f5d2110044a25bbd8c0ed598179f17cabcb29e64252f055a6223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>alpha-2-HS-Glycoprotein - genetics</topic><topic>alpha-2-HS-Glycoprotein - metabolism</topic><topic>Calcification</topic><topic>Cholesterol</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Nephropathies</topic><topic>Diabetic nephropathy</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Exons</topic><topic>Fasting</topic><topic>Fetuin-A</topic><topic>Genotype & phenotype</topic><topic>Glycoproteins</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Mutation</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Proteins</topic><topic>SNP</topic><topic>Statistical analysis</topic><topic>T2DM</topic><topic>α2-Heremans Schmid glycoprotein (AHSG)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umapathy, Dhamodharan</creatorcontrib><creatorcontrib>Subramanyam, Paridhy Vanniya</creatorcontrib><creatorcontrib>Krishnamoorthy, Ezhilarasi</creatorcontrib><creatorcontrib>Viswanathan, Vijay</creatorcontrib><creatorcontrib>Ramkumar, Kunka Mohanram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umapathy, Dhamodharan</au><au>Subramanyam, Paridhy Vanniya</au><au>Krishnamoorthy, Ezhilarasi</au><au>Viswanathan, Vijay</au><au>Ramkumar, Kunka Mohanram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Fetuin-A with Thr256Ser exon polymorphism of α2-Heremans Schmid Glycoprotein (AHSG) gene in type 2 diabetic patients with overt nephropathy</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2022-01</date><risdate>2022</risdate><volume>36</volume><issue>1</issue><spage>108074</spage><epage>108074</epage><pages>108074-108074</pages><artnum>108074</artnum><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Circulatory Fetuin-A has been well reported to elevate the risk for Diabetic Nephropathy (DN) and is associated with many vascular complications. Compelling reports have well documented that the circulatory levels of Fetuin-A directly have an impact on its AHSG (α2- Heremans- Schmid Glycoprotein) gene single nucleotide polymorphisms (SNP). Thus, in this study among the South Indian T2DM population, we aim to explore the association of AHSG Thr256Ser (rs4918) SNP in subjects with DN and correlate with the circulatory levels of Fetuin-A at various stages of DN patients.
A total of 975 subjects were recruited, such as Group-I, consisting of Controls (n = 300), Group-II, with normoalbuminuria (n = 300), Group-IIIa, with incipient microalbuminuria (n = 195), Group-IIIb, with persistent macroalbuminuria (n = 180)] and were subjected for genotyping using PCR-Restriction Fragment Length Polymorphism (RFLP). Circulatory Fetuin-A was measured using sandwich enzyme-linked immunosorbent assay (ELISA).
The ‘G’ allele of AHSG exon-7 (C/G) SNP is significantly concomitant and conferred significant risk for normoalbuminuria subjects. In the DN subjects, the ‘G' allele showed the risk for persistent macroalbuminuria. A noticeable stepwise decrease was evidenced in the circulatory Fetuin-A among persistent macroalbuminuria over incipient microalbuminuria from normoalbuminuria. Further, the circulatory Fetuin-A was lowered in DN subjects with mutant GG genotype than the wild CC.
AHSG Thr256Ser (rs4918) SNP was associated with renal complications among South Indian T2DM subjects.
•The association of AHSG Thr256Ser (rs4918) SNP in subjects with DN•Correlation of circulatory Fetuin-A at various stages of DN patients.•The circulatory Fetuin-A was found to be lowered in DN subjects with mutant GG genotype than the wild CC.•AHSG Thr256Ser (rs4918) SNP is associated with renal complications among South Indian T2DM subjects</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34774416</pmid><doi>10.1016/j.jdiacomp.2021.108074</doi><tpages>1</tpages></addata></record> |
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| ispartof | Journal of diabetes and its complications, 2022-01, Vol.36 (1), p.108074-108074, Article 108074 |
| issn | 1056-8727 1873-460X |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | alpha-2-HS-Glycoprotein - genetics alpha-2-HS-Glycoprotein - metabolism Calcification Cholesterol Creatinine Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetic Nephropathies Diabetic nephropathy Disease Enzymes Exons Fasting Fetuin-A Genotype & phenotype Glycoproteins High density lipoprotein Humans Insulin resistance Mutation Polymorphism Polymorphism, Single Nucleotide Population Proteins SNP Statistical analysis T2DM α2-Heremans Schmid glycoprotein (AHSG) |
| title | Association of Fetuin-A with Thr256Ser exon polymorphism of α2-Heremans Schmid Glycoprotein (AHSG) gene in type 2 diabetic patients with overt nephropathy |
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