Enhanced carboxypeptidase efficacies and differentiation of peptide epimers

Carboxypeptidases enzymatically cleave the peptide bond of C-terminal amino acids. In humans, it is involved in enzymatic synthesis and maturation of proteins and peptides. Carboxypeptidases A and Y have difficulty hydrolyzing the peptide bond of dipeptides and some other amino acid sequences. Early...

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Veröffentlicht in:	Analytical biochemistry 2022-04, Vol.642, p.114451-114451, Article 114451
Hauptverfasser:	Sung, Yu-Sheng, Putman, Joshua, Du, Siqi, Armstrong, Daniel W.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Aminoquinoline-N-Hydroxysuccimidyl carbamate Amino Acids - chemistry Amino Acids - metabolism Carboxypeptidases A - metabolism Cathepsin A - metabolism D-amino acid Enkephalin Humans LC-MS Mass Spectrometry Peptides Peptides - chemistry Peptides - metabolism
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