Optimization study of combined enteric and time-dependent polymethacrylates as a coating for colon targeted delivery of 5-ASA pellets in rats with ulcerative colitis

Formulation design for colon-specific delivery of 5-aminosalicylic acid (5-ASA) could bring some therapeutic benefits in the treatment of ulcerative colitis (UC). In the current study, a 32 full factorial design was used to predict optimum coating composed of two enteric (poly methacrylic acid, meth...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2022-01, Vol.168, p.106072-106072, Article 106072
Hauptverfasser:	Shahdadi Sardou, Hossein, Akhgari, Abbas, Mohammadpour, Amir Hooshang, Beheshti Namdar, Ali, Kamali, Hossein, Jafarian, Amir Hossein, Afrasiabi Garekani, Hadi, Sadeghi, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminosalicylic acid pellets Animals Colitis, Ulcerative - drug therapy Colon Colonic delivery Controlled release, polymethacrylates, Inulin Drug Delivery Systems Hydrogen-Ion Concentration Mesalamine - therapeutic use pH and time-dependent approach Polymethacrylic Acids Rats Solubility
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