Transdermal release of methotrexate by cationic starch/poly(vinyl alcohol)-based films as an approach for rheumatoid arthritis treatment

[Display omitted] Methotrexate (MTX) is a common drug used for rheumatoid arthritis (RA) treatment; however, a series of adverse effects associated with its oral or subcutaneous administration is reported. Transdermal delivery of MTX is an alternative to abate these issues, and the use of drug deliv...

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Veröffentlicht in:	International journal of pharmaceutics 2022-01, Vol.611, p.121285-121285, Article 121285
Hauptverfasser:	Nornberg, Andressa B., Martins, Carolina C., Cervi, Verônica F., Sari, Marcel H.M., Cruz, Letícia, Luchese, Cristiane, Wilhelm, Ethel A., Fajardo, André R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - drug therapy Biomaterials Cations CFA-induced arthritis Drug delivery In vivo model Methotrexate Mice Polysaccharides Polyvinyl Alcohol Starch
Online-Zugang:	Volltext
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