Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: An SEEG study
Periventricular nodular heterotopias (PVNH) are areas of neurons abnormally located in the white matter that might be involved in physiological cortical functions. Autoscopic hallucinations are changes in self-consciousness determined by a mismatch in integration of multiple sensory inputs. Our goal...
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Veröffentlicht in: | Cortex 2021-12, Vol.145, p.285-294 |
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creator | Bratu, Flavius-Ionut Oane, Irina Barborica, Andrei Donos, Cristian Pistol, Constantin Daneasa, Andrei Lentoiu, Camelia Mindruta, Ioana |
description | Periventricular nodular heterotopias (PVNH) are areas of neurons abnormally located in the white matter that might be involved in physiological cortical functions. Autoscopic hallucinations are changes in self-consciousness determined by a mismatch in integration of multiple sensory inputs. Our goal is to highlight the brain network involved in generation of autoscopic hallucination elicited by electrical stimulation of a PVNH in a drug resistant epilepsy patient.
Our patient was explored using stereo-electroencephalography with electrodes covering the right posterior temporal PVNH and the adjacent cortex. Direct electrical high frequency stimulation of the PVNH elicited autoscopic hallucinations mainly involving the face and upper trunk. We then used multiple modalities to determine brain connectivity: single pulse electrical stimulation of the PVNH and stimulation-evoked potentials were used to highlight resting state effective connectivity. High-frequency stimulation using alternating polarity pulses enabled us to identify the network involved, time-locked to the clinical effect and to map symptom-related effective connectivity. Functional connectivity using a non-linear regression method was used to determine dependencies between different cortical regions following the stimulation. Finally, structural connectivity was highlighted using deterministic fiber tracking.
Multi-modal connectivity analysis identified a network involving the PVNH, occipital and temporal neocortex, fusiform gyrus and parietal cortex.
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doi_str_mv | 10.1016/j.cortex.2021.08.018 |
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Our patient was explored using stereo-electroencephalography with electrodes covering the right posterior temporal PVNH and the adjacent cortex. Direct electrical high frequency stimulation of the PVNH elicited autoscopic hallucinations mainly involving the face and upper trunk. We then used multiple modalities to determine brain connectivity: single pulse electrical stimulation of the PVNH and stimulation-evoked potentials were used to highlight resting state effective connectivity. High-frequency stimulation using alternating polarity pulses enabled us to identify the network involved, time-locked to the clinical effect and to map symptom-related effective connectivity. Functional connectivity using a non-linear regression method was used to determine dependencies between different cortical regions following the stimulation. Finally, structural connectivity was highlighted using deterministic fiber tracking.
Multi-modal connectivity analysis identified a network involving the PVNH, occipital and temporal neocortex, fusiform gyrus and parietal cortex.
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Our patient was explored using stereo-electroencephalography with electrodes covering the right posterior temporal PVNH and the adjacent cortex. Direct electrical high frequency stimulation of the PVNH elicited autoscopic hallucinations mainly involving the face and upper trunk. We then used multiple modalities to determine brain connectivity: single pulse electrical stimulation of the PVNH and stimulation-evoked potentials were used to highlight resting state effective connectivity. High-frequency stimulation using alternating polarity pulses enabled us to identify the network involved, time-locked to the clinical effect and to map symptom-related effective connectivity. Functional connectivity using a non-linear regression method was used to determine dependencies between different cortical regions following the stimulation. Finally, structural connectivity was highlighted using deterministic fiber tracking.
Multi-modal connectivity analysis identified a network involving the PVNH, occipital and temporal neocortex, fusiform gyrus and parietal cortex.
[Display omitted]</description><subject>Bodily self-consciousness</subject><subject>Electroencephalography</subject><subject>Epilepsy surgery</subject><subject>Hallucinations</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Multi-modal connectivity</subject><subject>Neocortex</subject><subject>Periventricular nodular heterotopia</subject><subject>Periventricular Nodular Heterotopia - diagnostic imaging</subject><subject>SEEG</subject><issn>0010-9452</issn><issn>1973-8102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhiMEokvhDRDykUvC2LHXDgekqlraShUcgLPlTCaql2y82E7LHnlzXHbhyGmk0ff_o_mq6jWHhgNfv9s2GGKmn40AwRswDXDzpFrxTre14SCeVisADnUnlTirXqS0BRBglHpenbVSayXWalX9-kT5IcTvLIzMLTkkDHuP7M5N04J-dtmHOTGaPPpMA-sPzM85OqRIfXQTS9nvlumElY49RX9PBfFY1pHNYfgz7yhTDLmUu_fsYmZfNpurEl6Gw8vq2eimRK9O87z69nHz9fK6vv18dXN5cVtjuxa5lh0pENhyDlprdJ1DQU72PaGSwmiFoFCBFk5xKbvRmLF3cjC6Jy3VyNvz6u2xdx_Dj4VStjufkKbJzRSWZIXqtAFQShdUHlGMIaVIo91Hv3PxYDnYR_l2a4_y7aN8C8YW-SX25nRh6Xc0_Av9tV2AD0eAyp_3nqJN6GlGGnwkzHYI_v8XfgMpLprY</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Bratu, Flavius-Ionut</creator><creator>Oane, Irina</creator><creator>Barborica, Andrei</creator><creator>Donos, Cristian</creator><creator>Pistol, Constantin</creator><creator>Daneasa, Andrei</creator><creator>Lentoiu, Camelia</creator><creator>Mindruta, Ioana</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2181-062X</orcidid><orcidid>https://orcid.org/0000-0001-6783-3769</orcidid><orcidid>https://orcid.org/0000-0001-9329-5132</orcidid></search><sort><creationdate>202112</creationdate><title>Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: An SEEG study</title><author>Bratu, Flavius-Ionut ; Oane, Irina ; Barborica, Andrei ; Donos, Cristian ; Pistol, Constantin ; Daneasa, Andrei ; Lentoiu, Camelia ; Mindruta, Ioana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-49e502c3110777ca9ac2ea4bbec542875c05c5072a51449f88fba4d87be745f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bodily self-consciousness</topic><topic>Electroencephalography</topic><topic>Epilepsy surgery</topic><topic>Hallucinations</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Multi-modal connectivity</topic><topic>Neocortex</topic><topic>Periventricular nodular heterotopia</topic><topic>Periventricular Nodular Heterotopia - diagnostic imaging</topic><topic>SEEG</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bratu, Flavius-Ionut</creatorcontrib><creatorcontrib>Oane, Irina</creatorcontrib><creatorcontrib>Barborica, Andrei</creatorcontrib><creatorcontrib>Donos, Cristian</creatorcontrib><creatorcontrib>Pistol, Constantin</creatorcontrib><creatorcontrib>Daneasa, Andrei</creatorcontrib><creatorcontrib>Lentoiu, Camelia</creatorcontrib><creatorcontrib>Mindruta, Ioana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cortex</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bratu, Flavius-Ionut</au><au>Oane, Irina</au><au>Barborica, Andrei</au><au>Donos, Cristian</au><au>Pistol, Constantin</au><au>Daneasa, Andrei</au><au>Lentoiu, Camelia</au><au>Mindruta, Ioana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: An SEEG study</atitle><jtitle>Cortex</jtitle><addtitle>Cortex</addtitle><date>2021-12</date><risdate>2021</risdate><volume>145</volume><spage>285</spage><epage>294</epage><pages>285-294</pages><issn>0010-9452</issn><eissn>1973-8102</eissn><abstract>Periventricular nodular heterotopias (PVNH) are areas of neurons abnormally located in the white matter that might be involved in physiological cortical functions. Autoscopic hallucinations are changes in self-consciousness determined by a mismatch in integration of multiple sensory inputs. Our goal is to highlight the brain network involved in generation of autoscopic hallucination elicited by electrical stimulation of a PVNH in a drug resistant epilepsy patient.
Our patient was explored using stereo-electroencephalography with electrodes covering the right posterior temporal PVNH and the adjacent cortex. Direct electrical high frequency stimulation of the PVNH elicited autoscopic hallucinations mainly involving the face and upper trunk. We then used multiple modalities to determine brain connectivity: single pulse electrical stimulation of the PVNH and stimulation-evoked potentials were used to highlight resting state effective connectivity. High-frequency stimulation using alternating polarity pulses enabled us to identify the network involved, time-locked to the clinical effect and to map symptom-related effective connectivity. Functional connectivity using a non-linear regression method was used to determine dependencies between different cortical regions following the stimulation. Finally, structural connectivity was highlighted using deterministic fiber tracking.
Multi-modal connectivity analysis identified a network involving the PVNH, occipital and temporal neocortex, fusiform gyrus and parietal cortex.
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subjects | Bodily self-consciousness Electroencephalography Epilepsy surgery Hallucinations Humans Magnetic Resonance Imaging Multi-modal connectivity Neocortex Periventricular nodular heterotopia Periventricular Nodular Heterotopia - diagnostic imaging SEEG |
title | Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: An SEEG study |
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