Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation

•Repeated morphine treatment reduced MKP-1/3 expression in the spinal cord.•AM1241 increased the expression of spinal MKP-1/3 in morphine tolerant mice.•AM1241 reduced MAPK phosphorylation by increasing MKP-1/3 expression.•The effect of AM1241 on morphine tolerance was blocked by MKP-1/3 antagonist....

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Veröffentlicht in:	Neuroscience 2022-01, Vol.480, p.56-64
Hauptverfasser:	Kong, Qingling, Tian, Songyu, Ma, Chao, Wang, Guonian, Zhang, Mingyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Cannabinoid Receptor Agonists cannabinoid type 2 receptor Drug Tolerance Dual Specificity Phosphatase 1 Humans Mitogen-Activated Protein Kinases MKP1/3 Morphine - pharmacology morphine tolerance p38 Mitogen-Activated Protein Kinases proinflammatory cytokine Protein Phosphatase 1 Receptors, Cannabinoid
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