The Role of RAD6B and PEDF in Retinal Degeneration

•RAD6B deficiency induces retinal degeneration in mice.•RAD6B deficiency accelerates the senescence and apoptosis of retina.•The PEDF signal was changed in retina of the RAD6B deficient mice compared with the wild-type mice. RAD6B is an E2 ubiquitin-conjugating enzyme, playing an important role in D...

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Veröffentlicht in:	Neuroscience 2022-01, Vol.480, p.19-31
Hauptverfasser:	Ye, Qiang, Wang, Jiaqi, Liu, Xiangwen, Liu, Zihua, BaZong, LuoSong, Ma, Jinhai, Shen, Rong, Ye, Weichun, Zhang, Wenfang, Wang, Degui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis degeneration Eye Proteins - genetics Mice Nerve Growth Factors - genetics PEDF RAD6B Retina Retinal Degeneration senescence Serpins - genetics
Online-Zugang:	Volltext
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