Antidiabetic Effects of the Senolytic Agent Dasatinib

To evaluate the antidiabetic effects of the senolytic agent dasatinib in older patients with type 2 diabetes mellitus. This retrospective cohort study included enterprise-wide Mayo Clinic patients using Informatics for Integrating Biology at the Bedside from January 1994 through December 2019. The a...

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Veröffentlicht in:	Mayo Clinic proceedings 2021-12, Vol.96 (12), p.3021-3029
Hauptverfasser:	Salaami, Omid, Kuo, Chia-Ling, Drake, Matthew T., Kuchel, George A., Kirkland, James L., Pignolo, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - analysis Blood Glucose - drug effects Dasatinib Dasatinib - therapeutic use Diabetes Mellitus, Type 2 - drug therapy Dosage and administration Drug therapy Female Glycated Hemoglobin - analysis Glycated Hemoglobin - drug effects Glycemic Control Humans Hypoglycemic Agents - therapeutic use Imatinib Mesylate - therapeutic use Linear Models Male Middle Aged Patient outcomes Quercetin Retrospective Studies Senotherapeutics - therapeutic use Type 2 diabetes
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