Grade of sedation in the critically ill pediatric patient and its correlation with sociodemographic and clinical variables. Multicentre COSAIP study

To determine the grade of sedation in the critically ill paediatric patient using Biespectral Index Sensor (BIS) and to analyse its relationship with sociodemographic and clinical patient variables. Observational, analytical, cross-sectional and multicentre study performed from May 2018 to January 2020 in 5 Spanish paediatric critical care units. Sex, age, reason for admission, presence of a chronic pathology, type and number of drugs and length of stay were the sociodemographic and clinical variables registered. Furthermore, the grade of sedation was assessed using BIS, once per shift over 24 h. A total of 261 paediatric patients, 53.64% of whom were male, with a median age of 1.61 years (0.35–6.55), were included in the study. Of the patients, 70.11% (n = 183) were under analgosedation and monitored using the BIS sensor. A median of BIS values of 51.24 ± 14.96 during the morning and 50.75 ± 15.55 during the night were observed. When comparing BIS values and sociodemographic and clinical paediatric variables no statistical significance was detected. Despite the limitations of the BIS, investigations and the present study show that BIS could be a useful instrument to assess grade of sedation in critically ill paediatric patients. However, further investigations which determine the sociodemographic and clinical variables involved in the grade of paediatric analgosedation, as well as studies that contrast the efficacy of clinical scales like the COMFORT Behaviour Scale-Spanish version, are required. Determinar los niveles de sedación del paciente crítico pediátrico mediante el sensor BIS y analizar la relación entre grado de sedación y las variables sociodemográficas y clínicas del paciente. Estudio observacional, analítico, transversal y multicéntrico de mayo de 2018 a enero de 2020 realizo en cinco Unidades de Cuidados Intensivos Pediátricas del territorio español. Se registraron como variables sociodemográficas y clínicas el sexo, la edad, motivo de ingreso, si el paciente tenía patología crónica, tipo y número de fármacos que se le estaba administrando. Además, se anotaron los valores del BIS una vez por turno, mañana y noche, durante 24 h. Se incluyeron en el estudio un total de 261 pacientes, de los cuáles el 53,64% eran del sexo masculino, con una edad mediana de 1,61 años (0,35–6,55). El 70,11% (n = 183) estaban analgosedados y monitorizados con el sensor BIS. Se observó una mediana en las puntuaciones globales de BIS de 51,24 ± 14,96 en el turno de