Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades
The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, looking at all hospitalizations in persons with HIV (PWH) in Spain. A retrospective study usin...
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| Veröffentlicht in: | AIDS (London) 2022-02, Vol.36 (2), p.249-256 |
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| creator | Ramos-Rincon, José-Manuel Menchi-Elanzi, Maroune Pinargote-Celorio, Héctor Mayoral, Asunción González-Alcaide, Gregorio de Mendoza, Carmen Barreiro, Pablo Gómez-Gallego, Félix Corral, Octavio Soriano, Vicente |
| description | The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, looking at all hospitalizations in persons with HIV (PWH) in Spain.
A retrospective study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997-2018.
From 79 647 783 nationwide hospital admissions recorded during the study period, 532 668 (0.67%) included HIV as diagnosis. The mean age of PWH hospitalized increased from 33 to 51 years (P |
| doi_str_mv | 10.1097/QAD.0000000000003105 |
| format | Article |
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A retrospective study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997-2018.
From 79 647 783 nationwide hospital admissions recorded during the study period, 532 668 (0.67%) included HIV as diagnosis. The mean age of PWH hospitalized increased from 33 to 51 years (P < 0.001). The rate of HIV hospitalizations significantly declined after 2008. Comparing hospitalizations during the first (1997-2007) and last (2008-2018) decades, the rate of non-AIDS illnesses increased, mostly due to liver disease (from 35.9 to 38.3%), cardiovascular diseases (from 12.4 to 28.2%), non-AIDS cancers (from 6.4 to 15.5%), and kidney insufficiency (from 5.4 to 13%). In-hospital deaths occurred in 5.5% of PWH, declining significantly over time. Although most deaths were the result from AIDS conditions (34.8%), the most frequent non-AIDS deaths were liver disease (47.1%), cardiovascular events (29.2%), non-AIDS cancers (24.2%), and kidney insufficiency (20.7%).
Hospital admissions in PWH significantly declined after 2008, following improvements in HIV management and antiretroviral therapy. Non-AIDS cancers, cardiovascular events and liver disease represent a growing proportion of hospital admissions and deaths in PWH.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000003105</identifier><identifier>PMID: 34762389</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins</publisher><subject>Acquired Immunodeficiency Syndrome ; Adult ; HIV Infections - complications ; HIV Infections - drug therapy ; Hospitalization ; Humans ; Middle Aged ; Retrospective Studies ; Spain - epidemiology</subject><ispartof>AIDS (London), 2022-02, Vol.36 (2), p.249-256</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3520-5f6a4d831d6b9f7d326e709009a63dbeb3a942051fa8f05c887bd891f28225333</citedby><cites>FETCH-LOGICAL-c3520-5f6a4d831d6b9f7d326e709009a63dbeb3a942051fa8f05c887bd891f28225333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34762389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos-Rincon, José-Manuel</creatorcontrib><creatorcontrib>Menchi-Elanzi, Maroune</creatorcontrib><creatorcontrib>Pinargote-Celorio, Héctor</creatorcontrib><creatorcontrib>Mayoral, Asunción</creatorcontrib><creatorcontrib>González-Alcaide, Gregorio</creatorcontrib><creatorcontrib>de Mendoza, Carmen</creatorcontrib><creatorcontrib>Barreiro, Pablo</creatorcontrib><creatorcontrib>Gómez-Gallego, Félix</creatorcontrib><creatorcontrib>Corral, Octavio</creatorcontrib><creatorcontrib>Soriano, Vicente</creatorcontrib><title>Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, looking at all hospitalizations in persons with HIV (PWH) in Spain.
A retrospective study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997-2018.
From 79 647 783 nationwide hospital admissions recorded during the study period, 532 668 (0.67%) included HIV as diagnosis. The mean age of PWH hospitalized increased from 33 to 51 years (P < 0.001). The rate of HIV hospitalizations significantly declined after 2008. Comparing hospitalizations during the first (1997-2007) and last (2008-2018) decades, the rate of non-AIDS illnesses increased, mostly due to liver disease (from 35.9 to 38.3%), cardiovascular diseases (from 12.4 to 28.2%), non-AIDS cancers (from 6.4 to 15.5%), and kidney insufficiency (from 5.4 to 13%). In-hospital deaths occurred in 5.5% of PWH, declining significantly over time. Although most deaths were the result from AIDS conditions (34.8%), the most frequent non-AIDS deaths were liver disease (47.1%), cardiovascular events (29.2%), non-AIDS cancers (24.2%), and kidney insufficiency (20.7%).
Hospital admissions in PWH significantly declined after 2008, following improvements in HIV management and antiretroviral therapy. Non-AIDS cancers, cardiovascular events and liver disease represent a growing proportion of hospital admissions and deaths in PWH.</description><subject>Acquired Immunodeficiency Syndrome</subject><subject>Adult</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Spain - epidemiology</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUNtKxDAQDaLoevkDkT760nWSNE3yKN5BEHEV30raTNlqt61J1kW_3rjrDYdhBuZcBg4h-xTGFLQ8uj0-HcOf4hTEGhnRTPJUCEnXyQhYrlPNJWyRbe-fIkmAUptki2cyZ1zpEXmcOOysT5oumfZ-aIJpm3cTmr7zielsYtGE6RK-vHpIm67GKqBNhkjBLiyBu8HE2b-iS8Kij4rKWPS7ZKM2rce9r71D7s_PJieX6fXNxdXJ8XVaccEgFXVuMqs4tXmpa2k5y1GCBtAm57bEkhudMRC0NqoGUSklS6s0rZliTHDOd8jhyndw_cscfShmja-wbU2H_dwXTGiZacUyFqnZilq53nuHdTG4ZmbcW0Gh-My0iJkW_zONsoOvD_NyhvZH9B3ir--ibwM6_9zOF-iKKZo2TJd-DDikDFhsoJDGCwX-Aa9tgDY</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ramos-Rincon, José-Manuel</creator><creator>Menchi-Elanzi, Maroune</creator><creator>Pinargote-Celorio, Héctor</creator><creator>Mayoral, Asunción</creator><creator>González-Alcaide, Gregorio</creator><creator>de Mendoza, Carmen</creator><creator>Barreiro, Pablo</creator><creator>Gómez-Gallego, Félix</creator><creator>Corral, Octavio</creator><creator>Soriano, Vicente</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades</title><author>Ramos-Rincon, José-Manuel ; Menchi-Elanzi, Maroune ; Pinargote-Celorio, Héctor ; Mayoral, Asunción ; González-Alcaide, Gregorio ; de Mendoza, Carmen ; Barreiro, Pablo ; Gómez-Gallego, Félix ; Corral, Octavio ; Soriano, Vicente</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3520-5f6a4d831d6b9f7d326e709009a63dbeb3a942051fa8f05c887bd891f28225333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acquired Immunodeficiency Syndrome</topic><topic>Adult</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos-Rincon, José-Manuel</creatorcontrib><creatorcontrib>Menchi-Elanzi, Maroune</creatorcontrib><creatorcontrib>Pinargote-Celorio, Héctor</creatorcontrib><creatorcontrib>Mayoral, Asunción</creatorcontrib><creatorcontrib>González-Alcaide, Gregorio</creatorcontrib><creatorcontrib>de Mendoza, Carmen</creatorcontrib><creatorcontrib>Barreiro, Pablo</creatorcontrib><creatorcontrib>Gómez-Gallego, Félix</creatorcontrib><creatorcontrib>Corral, Octavio</creatorcontrib><creatorcontrib>Soriano, Vicente</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos-Rincon, José-Manuel</au><au>Menchi-Elanzi, Maroune</au><au>Pinargote-Celorio, Héctor</au><au>Mayoral, Asunción</au><au>González-Alcaide, Gregorio</au><au>de Mendoza, Carmen</au><au>Barreiro, Pablo</au><au>Gómez-Gallego, Félix</au><au>Corral, Octavio</au><au>Soriano, Vicente</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>36</volume><issue>2</issue><spage>249</spage><epage>256</epage><pages>249-256</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>The prognosis of HIV infection dramatically improved after the introduction of triple antiretroviral therapy 25 years ago. Herein, we report the impact of further improvements in HIV management since then, looking at all hospitalizations in persons with HIV (PWH) in Spain.
A retrospective study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997-2018.
From 79 647 783 nationwide hospital admissions recorded during the study period, 532 668 (0.67%) included HIV as diagnosis. The mean age of PWH hospitalized increased from 33 to 51 years (P < 0.001). The rate of HIV hospitalizations significantly declined after 2008. Comparing hospitalizations during the first (1997-2007) and last (2008-2018) decades, the rate of non-AIDS illnesses increased, mostly due to liver disease (from 35.9 to 38.3%), cardiovascular diseases (from 12.4 to 28.2%), non-AIDS cancers (from 6.4 to 15.5%), and kidney insufficiency (from 5.4 to 13%). In-hospital deaths occurred in 5.5% of PWH, declining significantly over time. Although most deaths were the result from AIDS conditions (34.8%), the most frequent non-AIDS deaths were liver disease (47.1%), cardiovascular events (29.2%), non-AIDS cancers (24.2%), and kidney insufficiency (20.7%).
Hospital admissions in PWH significantly declined after 2008, following improvements in HIV management and antiretroviral therapy. Non-AIDS cancers, cardiovascular events and liver disease represent a growing proportion of hospital admissions and deaths in PWH.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34762389</pmid><doi>10.1097/QAD.0000000000003105</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acquired Immunodeficiency Syndrome Adult HIV Infections - complications HIV Infections - drug therapy Hospitalization Humans Middle Aged Retrospective Studies Spain - epidemiology |
| title | Trends in hospitalizations and deaths in HIV-infected patients in Spain over two decades |
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