c-Myc-activated intronic miR-210 and lncRNA MIR210HG synergistically promote the metastasis of gastric cancer

The relationship between microRNA (miRNA) and hosting long non-coding RNA (lncRNA) remains unclear. Here, the expression levels of microRNA-210 (miR-210) and hosting lncRNA MIR210HG are significantly increased and positively correlated in gastric cancer (GC). Gain- and loss-of-function studies demon...

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Veröffentlicht in:	Cancer letters 2022-02, Vol.526, p.322-334
Hauptverfasser:	Li, Zhi-Yong, Xie, Ying, Deng, Mingxia, Zhu, Leqing, Wu, Xiaobin, Li, Guangqiang, Shi, Nan-Xi, Wen, Chuangyu, Huang, Weicai, Duan, Yuanyuan, Yin, Zhinan, Lin, Xue-Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Binding sites c-Jun protein c-Myc protein Cell Line, Tumor DNA helicase Dopamine D5 receptors Female Gastric cancer Gene expression Genes, myc Genomes Heterografts Humans Hypoxia Introns Kinases Laboratory animals Lung cancer Metastases Metastasis Mice Mice, Inbred NOD Mice, SCID microRNA-210 MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism MIR210HG miRNA Myc protein Neoplasm Metastasis Non-coding RNA Polymerase chain reaction Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA, Long Noncoding - genetics Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Synergistic function Transcription factors Transcriptional regulation Tumorigenesis
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