Molecular characteristics of several drugs evaluated from solvent/water partition measurements: Solvation parameters and intramolecular hydrogen bond indicator

•Drug experimental partition in solvent/water (octanol, chloroform, toluene, dodecane).•Derivation of drug solvation parameters from partition values.•Derivation of intramolecular hydrogen bond indicator from partition parameters.•Estimation of toluene/water partition by means of Minnesota's so...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2022-01, Vol.168, p.106066-106066, Article 106066
Hauptverfasser:	Ruiz, Rebeca, Zamora, William J., Ràfols, Clara, Bosch, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Octanol Abraham descriptors of drugs Hydrogen Bonding Implicit solvation models Intramolecular hydrogen bond indicator Pharmaceutical Preparations SMD Solvent partition of drugs Solvents Water
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